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Subgingival instrumentation, with or without surgical access, is the gold\u2010standard treatment for periodontitis. The aim was to summarize the evidence on the effect of subgingival instrumentation (with or without open flap) on the reduction of glycosylated haemoglobin (HbA1c).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine electronic databases were searched up to 15 February 2023. Twelve randomized controlled trials with at least 6\u2009months of follow\u2010up were included. Studies using systemic or local\u2010delivery antimicrobial therapies were excluded. Meta\u2010analyses were performed using the random\u2010effects model. The sources of heterogeneity were assessed by applying linear meta\u2010regression. Risk of bias was assessed by RoB 2, and certainty of evidence by GRADE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven studies were included in the quantitative analyses (1374 patients). Subgingival instrumentation resulted in 0.29% lower HbA1c (95% confidence interval: 0.10\u20130.47; <jats:italic>p<\/jats:italic>\u2009=\u2009.03) compared with non\u2010active treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>None of the 12 studies were assessed as having low risk of bias. The percentage of females and the time of diabetes diagnosis significantly explained the high level of heterogeneity. Subgingival periodontal therapy results in a significant and clinically relevant improvement in glycaemic control over 6\u2009months in patients with T2DM and periodontitis. The grade of evidence was moderate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13830","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:45:03Z","timestamp":1685580303000},"page":"1123-1137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effect of subgingival periodontal therapy on glycaemic control in type 2 diabetes patients: Meta\u2010analysis and meta\u2010regression of 6\u2010month follow\u2010up randomized clinical trials"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5812-5645","authenticated-orcid":false,"given":"Victor Bento","family":"Oliveira","sequence":"first","affiliation":[{"name":"Graduate Program in Dentistry, Faculty of Pharmacy, Dentistry and Nursing Federal University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3262-3347","authenticated-orcid":false,"given":"F\u00e1bio Wildson Gurgel","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Clinical Dentistry, Faculty of Pharmacy, Dentistry and Nursing Federal University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0531-6234","authenticated-orcid":false,"given":"Alex Nogueira","family":"Haas","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Faculty of Dentistry Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7287-8726","authenticated-orcid":false,"given":"Renan Magalh\u00e3es Montenegro","family":"J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Medicine Federal University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5250-5738","authenticated-orcid":false,"given":"Rodrigo Ot\u00e1vio","family":"R\u00eago","sequence":"additional","affiliation":[{"name":"Department of Clinical Dentistry, Faculty of Pharmacy, Dentistry and Nursing Federal University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,31]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-016-2086-5"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-S002"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128344"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107BOR-2015.vol29.0071"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-7757-2019-0248"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2005.10.012"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.1340013"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2542-5196(21)00280-1"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12517"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dcS15-3007"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-019-0829-y"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2015.07.002"},{"key":"e_1_2_12_14_1","first-page":"107","article-title":"The relationship between diabetes mellitus and destructive periodontal disease: A meta\u2010analysis","volume":"7","author":"Chavarry N. 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