{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:15:14Z","timestamp":1789769714161,"version":"4.0.1"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFC1806904"],"award-info":[{"award-number":["2020YFC1806904"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42077382"],"award-info":[{"award-number":["42077382"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p><jats:italic>Porphyromonas gingivalis<\/jats:italic> (<jats:italic>P. gingivalis<\/jats:italic>), a major periodontal pathogen, increases the risk of systemic diseases. <jats:italic>P. gingivalis<\/jats:italic> infection is closely associated with alcoholic liver disease (ALD), but the underlying mechanism remains unclear. We aimed to investigate the role of <jats:italic>P. gingivalis<\/jats:italic> in the pathogenesis of ALD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>An ALD mouse model was established using a Lieber\u2010DeCarli liquid diet, and C57BL\/6 mice were treated with <jats:italic>P. gingivalis<\/jats:italic> to detect the pathological indicators of ALD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Oral administration of <jats:italic>P. gingivalis<\/jats:italic> exacerbated alcohol\u2010induced alterations in the gut microbiota, leading to gut barrier dysfunction and inflammatory response and disruption of the T\u2010helper 17 cell\/T\u2010regulatory cell ratio in the colon of ALD mice. Furthermore, <jats:italic>P. gingivalis<\/jats:italic> worsened liver inflammation in ALD mice by increasing the protein expression of toll\u2010like receptor 4 (TLR4) and p65, increasing the mRNA expression of interleukins\u20106 (IL\u20106) and tumour necrosis factor\u2010alpha (TNF\u2010\u03b1) and up\u2010regulating the transforming growth factor\u2010beta 1 (TGF\u2010\u03b21) and galectin\u20103 (Gal\u20103) production.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results indicate that <jats:italic>P. gingivalis<\/jats:italic> accelerates the pathogenesis of ALD via the oral\u2013gut\u2013liver axis, necessitating a new treatment strategy for patients with ALD complicated by periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13833","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T06:20:48Z","timestamp":1688019648000},"page":"1253-1263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["<i>Porphyromonas gingivalis<\/i> exacerbates alcoholic liver disease by altering gut microbiota composition and host immune response in mice"],"prefix":"10.1111","volume":"50","author":[{"given":"Yuting","family":"Gao","sequence":"first","affiliation":[{"name":"College of Environmental Sciences and Engineering Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Environmental Sciences and Engineering Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Medicine Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaolin","family":"Ye","sequence":"additional","affiliation":[{"name":"School of Medicine Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0313-0129","authenticated-orcid":false,"given":"Daqing","family":"Mao","sequence":"additional","affiliation":[{"name":"School of Medicine Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2862-7887","authenticated-orcid":false,"given":"Dasheng","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tianjin First Central Hospital, Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7707-708X","authenticated-orcid":false,"given":"Yi","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Environmental Sciences and Engineering Nankai University  Tianjin China"},{"name":"State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2707"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.94416"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.2007042"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137249"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep04828"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0099-1"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(87)80003-X"},{"issue":"1","key":"e_1_2_11_9_1","first-page":"30","article-title":"Jejunal microflora in patients with chronic alcohol abuse","volume":"31","author":"Bode J. 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