{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:17:10Z","timestamp":1790731030590,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EH 365 1\u20101"],"award-info":[{"award-number":["EH 365 1\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Assessment of treatment response after systemic amoxicillin\/metronidazole adjunctive to subgingival instrumentation (SI) according to stages and grades of the 2018 classification of periodontal diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We carried out exploratory re\u2010analysis of the placebo\u2010controlled, multi\u2010centre ABPARO trial (52; 45\/60\u2009years of age; 205 males, 114 active smokers). Patients were randomized to SI with systemic amoxicillin 500\u2009mg\/metronidazole 400\u2009mg (three times a day for 7\u2009days, <jats:italic>n<\/jats:italic>\u2009=\u2009205; ANTI) or placebo (<jats:italic>n<\/jats:italic>\u2009=\u2009200; PLAC) and maintenance therapy every 3\u2009months. Patients were reclassified according to the 2018 classification (stage\/extent\/grade). Treatment effect was the percentage of sites per patient with new attachment loss \u22651.3\u2009mm (PSAL\u2009\u2265\u20091.3\u2009mm) at 27.5\u2009months post\u2010baseline\/randomization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients were assigned according to the stage (<jats:italic>n<\/jats:italic>\u2009=\u200949 localized stage III, <jats:italic>n<\/jats:italic>\u2009=\u2009206 generalized stage III, <jats:italic>n<\/jats:italic>\u2009=\u2009150 stage IV). Because of missing radiographs, only 222 patients were assigned to grades (<jats:italic>n<\/jats:italic>\u2009=\u200973 B, <jats:italic>n<\/jats:italic>\u2009=\u2009149 C). Treatment (PLAC\/ANTI) resulted in PSAL\u2009\u2265\u20091.3\u2009mm (median; lower\/upper quartile) in localized stage III (PLAC: 5.7; 3.3\/8.4% vs. ANTI: 4.9; 3.0\/8.3%; <jats:italic>p<\/jats:italic>\u2009=\u2009.749), generalized stage III (8.0; 4.5\/14.3% vs. 4.7; 2.4\/9.0%; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), stage IV (8.5; 5.1\/14.4% vs. 5.7; 3.3\/10.6%; <jats:italic>p<\/jats:italic>\u2009=\u2009.008), grade B (4.4; 2.4\/6.7% vs. 3.6; 1.9\/4.7%; <jats:italic>p<\/jats:italic>\u2009=\u2009.151) and grade C (9.4; 5.3\/14.3% vs. 4.8; 2.5\/9.4%; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In generalized periodontitis stage III\/grade C, a clinically relevant lower percentage of disease progression after adjunctive systemic amoxicillin\/metronidazole was observed compared to placebo (PLAC: 9.7; 5.8\/14.3% vs. ANTI: 4.7; 2.4\/9.0%; <jats:italic>p<\/jats:italic> &lt; .001).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13838","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T10:34:20Z","timestamp":1686306860000},"page":"1239-1252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Clinical benefits of systemic amoxicillin\/metronidazole may depend on periodontitis stage and grade: An exploratory sub\u2010analysis of the ABPARO trial"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1655-8055","authenticated-orcid":false,"given":"Peter","family":"Eickholz","sequence":"first","affiliation":[{"name":"Department of Periodontology Johann Wolfgang Goethe\u2010University Frankfurt am Main  Frankfurt am Main Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Koch","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Clinical Research University of M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"G\u00f6de","sequence":"additional","affiliation":[{"name":"Department of Periodontology Johann Wolfgang Goethe\u2010University Frankfurt am Main  Frankfurt am Main Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3785-8364","authenticated-orcid":false,"given":"Katrin","family":"Nickles","sequence":"additional","affiliation":[{"name":"Department of Periodontology Johann Wolfgang Goethe\u2010University Frankfurt am Main  Frankfurt am Main Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kocher","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry University Medicine Greifswald  Greifswald 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