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Tree shrews, evolutionarily closer to humans than commonly used rodent models, have been increasingly used as biomedical models. However, a tree shrew periodontitis model has not yet been established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Periodontitis was induced in male tree shrews\/Sprague\u2013Dawley rats by nylon thread ligature placement around the lower first molars. Thereafter, morphometric and histological analyses were performed. The distance from the cemento\u2010enamel junction to the alveolar bone crest was measured using micro\u2010computed tomography. Periodontal pathological tissue damage, inflammation and osteoclastogenesis were assessed using haematoxylin and eosin staining and quantitative immunohistochemistry, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Post\u2010operatively, gingival swelling, redness and spontaneous bleeding were observed in tree shrews but not in rats. After peaking, bone resorption decreased gradually until plateauing in tree shrews. Contrastingly, rapid and near\u2010complete bone loss was observed in rats. Inflammatory infiltrates were observed 1\u2009week post operation in both models. However, only the tree shrew model transitioned from acute to chronic inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study revealed that a ligature\u2010induced tree shrew model of periodontitis partly reproduced the pathological features of human periodontitis and provided theoretical support for using tree shrews as a potential model for human periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13842","type":"journal-article","created":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T01:32:29Z","timestamp":1687656749000},"page":"1075-1088","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The tree shrew as a new animal model for the study of periodontitis"],"prefix":"10.1111","volume":"50","author":[{"given":"Liya","family":"Ma","sequence":"first","affiliation":[{"name":"Yunnan Key Laboratory of Stomatology and Department of Dental Research The Affiliated 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