{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T16:03:05Z","timestamp":1774713785316,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Patients with systemic sclerosis (SSc) present various clinical and radiological oral manifestations. However, precise evaluation of the oral features associated with diffuse cutaneous SSc (dcSSc) and limited cutaneous SSc (lcSSc) is limited. The objective of this study was to evaluate the periodontal ligament (PDL) surface in SSc patients in comparison with controls. Assessment of oral\u2010health\u2010related quality of life (OHRQoL) and the levels of different biomarkers in the gingival crevicular fluid (GCF) was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>SSc patients and matched controls underwent standardized oral examination and cone\u2010beam computed tomography (CBCT). Levels of interleukin\u20106 (IL\u20106), chemokine (C\u2010X\u2010C motif) ligand 4 (CXCL\u20104) and matrix metalloproteinase\u20109 (MMP\u20109) in the GCF were determined by enzyme\u2010linked immunosorbent assay. PDL surface was measured on CBCT axial views. OHRQoL was quantified using the Mouth Handicap in SSc Scale (MHISS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010nine SSc patients and 39 controls were included. SSc patients exhibited increased PDL surface, higher number of missing teeth as well as elevated IL\u20106, MMP\u20109 and CXCL\u20104 levels. Reduced mouth opening was observed in dcSSc but not in lcSSc patients. MHISS score was higher in dcSSc than in lcSSc patients. Although worse periodontal parameters were found in both subgroups compared with controls, dcSSc patients presented lower gingival inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SSc is associated with PDL space widening, impaired oral health and OHRQoL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13846","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T11:09:30Z","timestamp":1689073770000},"page":"1348-1359","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Influence of systemic sclerosis on periodontal health: A case\u2013control study"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7925-1077","authenticated-orcid":false,"given":"Sophie","family":"Jung","sequence":"first","affiliation":[{"name":"Facult\u00e9 de Chirurgie Dentaire Robert Frank Universit\u00e9 de Strasbourg  Strasbourg France"},{"name":"P\u00f4le de M\u00e9decine et de Chirurgie bucco\u2010dentaires, Centre de R\u00e9f\u00e9rence des maladies rares orales et dentaires (O\u2010Rares) H\u00f4pitaux Universitaires de Strasbourg  Strasbourg France"},{"name":"INSERM UMR_S 1109 \u201cMolecular ImmunoRheumatology\u201d, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), LabEx TRANSPLANTEX  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Gavriiloglou","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de Chirurgie Dentaire Robert Frank Universit\u00e9 de Strasbourg  Strasbourg France"},{"name":"Unit\u00e9 Fonctionnelle de Parodontologie, P\u00f4le de M\u00e9decine et de Chirurgie bucco\u2010dentaires H\u00f4pitaux Universitaires de Strasbourg  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"S\u00e9verac","sequence":"additional","affiliation":[{"name":"Groupe M\u00e9thodes en Recherche Clinique (GMRC) H\u00f4pitaux Universitaires de Strasbourg  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucille","family":"Haumesser","sequence":"additional","affiliation":[{"name":"Groupe M\u00e9thodes en Recherche Clinique (GMRC) H\u00f4pitaux Universitaires de Strasbourg  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amira","family":"Sayeh","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Fonctionnelle de Radiologie, P\u00f4le de M\u00e9decine et de Chirurgie bucco\u2010dentaires H\u00f4pitaux Universitaires de Strasbourg  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Chatelus","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, Centre de R\u00e9f\u00e9rence des maladies autoimmunes syst\u00e9miques rares (RESO) H\u00f4pitaux Universitaires de Strasbourg  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Martin","sequence":"additional","affiliation":[{"name":"INSERM UMR_S 1109 \u201cMolecular ImmunoRheumatology\u201d, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), LabEx TRANSPLANTEX  Strasbourg France"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Strasbourg  Strasbourg France"},{"name":"Service d'Immunologie Clinique, Centre de R\u00e9f\u00e9rence des Maladies Auto\u2010immunes Syst\u00e9miques Rares (RESO) H\u00f4pitaux Universitaires de Strasbourg  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7988-2290","authenticated-orcid":false,"given":"Olivier","family":"Huck","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de Chirurgie Dentaire Robert Frank Universit\u00e9 de Strasbourg  Strasbourg France"},{"name":"Unit\u00e9 Fonctionnelle de Parodontologie, P\u00f4le de M\u00e9decine et de Chirurgie bucco\u2010dentaires H\u00f4pitaux Universitaires de Strasbourg  Strasbourg France"},{"name":"F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS) INSERM UMR 1260 \u201cRegenerative Nanomedicine\u201d  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(84)90375-X"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr\/64340754"},{"issue":"2","key":"e_1_2_13_4_1","first-page":"203","article-title":"Sj\u00f6gren's syndrome in rheumatoid arthritis and progressive systemic sclerosis. 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