{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:54:01Z","timestamp":1773388441299,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000043","name":"American Association for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000043","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01 DE11551"],"award-info":[{"award-number":["R01 DE11551"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN268201700001I"],"award-info":[{"award-number":["HHSN268201700001I"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN268201700002I"],"award-info":[{"award-number":["HHSN268201700002I"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN268201700003I"],"award-info":[{"award-number":["HHSN268201700003I"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN268201700004I"],"award-info":[{"award-number":["HHSN268201700004I"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN268201700005I"],"award-info":[{"award-number":["HHSN268201700005I"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate individual susceptibility to periodontitis by conducting an epigenome\u2010wide association study using peripheral blood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We included 1077 African American and 457 European American participants of the Atherosclerosis Risk in Communities (ARIC) study who had completed a dental examination or reported being edentulous at Visit 4 and had available data on DNA methylation from Visit 2 or 3. DNA methylation levels were compared by periodontal disease severity and edentulism through discovery analyses and subsequent testing of individual CpGs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our discovery analysis replicated findings from a previous study reporting a region in gene\n                      <jats:italic>ZFP57<\/jats:italic>\n                      (6p22.1) that was significantly hypomethylated in severe periodontal disease compared with no\/mild periodontal disease in European American participants. Higher methylation levels in a separate region in an unknown gene (located in Chr10: 743,992\u2010744,958) was associated with significantly higher odds of edentulism compared with no\/mild periodontal disease in African American participants. In subsequent CpG testing, four CpGs in a region previously associated with periodontitis located within\n                      <jats:italic>HOXA4<\/jats:italic>\n                      were significantly hypermethylated in severe periodontal disease compared with no\/mild periodontal disease in African American participants (odds ratio per 1 SD increase in methylation level: cg11015251: 1.28 (1.02, 1.61); cg14359292: 1.24 (1.01, 1.54); cg07317062: 1.30 (1.05, 1.61); cg08657492: 1.25 (1.01, 1.55)).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our study highlights epigenetic variations in\n                      <jats:italic>ZPF57<\/jats:italic>\n                      and\n                      <jats:italic>HOXA4<\/jats:italic>\n                      that are significantly and reproducibly associated with periodontitis. Future studies should evaluate gene regulatory mechanisms in the candidate regions of these loci.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.13852","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:48:12Z","timestamp":1689727692000},"page":"1140-1153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Epigenome\u2010wide association study using peripheral blood leukocytes identifies genomic regions associated with periodontal disease and edentulism in the Atherosclerosis Risk in Communities study"],"prefix":"10.1111","volume":"50","author":[{"given":"Naisi","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Public Health &amp; Community Medicine, Tufts University School of Medicine Tufts University  Boston Massachusetts 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T.","family":"Kelsey","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Brown University  Providence Rhode Island USA"},{"name":"Department of Pathology and Laboratory Medicine Brown University  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Platz","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"},{"name":"The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique S.","family":"Michaud","sequence":"additional","affiliation":[{"name":"Department of Public Health &amp; Community Medicine, Tufts University School of Medicine Tufts University  Boston Massachusetts 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