{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:51:20Z","timestamp":1791229880114,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To retrospectively investigate the relationship between the CD4+ T\u2010cell counts at baseline and the efficacy of the initial periodontal treatment of patients undergoing treatment for human immunodeficiency virus (HIV) infection using the periodontal inflamed surface area (PISA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Thirty\u2010three patients with chronic periodontitis who had undergone periodontal examination at baseline and after the initial periodontal treatment were enrolled. PISA was calculated from the periodontal probing depth and bleeding on probing, and the ratio of PISA after treatment to that at baseline (PISA response ratio) was calculated. Groups with a response ratio of &lt;1 and \u22651 were defined as the improvement and the non\u2010improvement groups, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PISA after the initial periodontal treatment significantly decreased compared with that at baseline (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). A weak negative correlation was found between the PISA response ratio and CD4+ T\u2010cell counts at baseline (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The CD4+ T\u2010cell counts at baseline were significantly higher in the improvement group than in the non\u2010improvement group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Multivariate analysis revealed that the CD4+ T\u2010cell counts at baseline was an independent factor that affects the PISA (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The higher the CD4+ T\u2010cell counts at baseline in patients undergoing treatment for HIV infection, the more effective the initial periodontal treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13873","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T01:58:06Z","timestamp":1693879086000},"page":"1520-1529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Relationship between <scp>CD4<\/scp>+ T\u2010cell counts at baseline and initial periodontal treatment efficacy in patients undergoing treatment for <scp>HIV<\/scp> infection: A retrospective observational study"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0789-3273","authenticated-orcid":false,"given":"Tomoaki","family":"Shintani","sequence":"first","affiliation":[{"name":"Center of Oral Clinical Examination Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Okada","sequence":"additional","affiliation":[{"name":"Division of Dental Hygiene, Department of Clinical Practice and Support Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7345-7480","authenticated-orcid":false,"given":"Tomoyuki","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Periodontal Medicine, Graduate School of Biomedical &amp; 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