{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:11:07Z","timestamp":1789495867894,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002050","name":"Delta Dental Foundation","doi-asserted-by":"publisher","award":["AWD010089"],"award-info":[{"award-number":["AWD010089"]}],"id":[{"id":"10.13039\/100002050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the Doppler ultrasonographic tissue perfusion at dental implant sites augmented with connective tissue graft (CTG) using coronally advanced flap (CAF) or tunnel technique (TUN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Twenty\u2010eight patients presenting with isolated healthy peri\u2010implant soft\u2010tissue dehiscence (PSTD) were included in this randomized clinical trial. PSTDs were treated with either CAF\u2009+\u2009CTG or TUN\u2009+\u2009CTG. Ultrasound scans were taken at baseline, 1\u2009week, 1\u2009month, 6\u2009months and 12\u2009months. Tissue perfusion at the mid\u2010facial, mesial and distal aspects of the implant sites was assessed by colour Doppler velocity (CDV) and power Doppler imaging (PDI). Early vascularization of the graft and the flap at 1\u2009week and at 1\u2009month were evaluated via dynamic tissue perfusion measurements (DTPMs), including\u00a0flow intensity (FI), mean perfusion relief intensity (pRI) and mean perfused area (pA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Regression analysis did not reveal significant differences in terms of mid\u2010facial CDV and PDI changes between CAF and TUN over 12\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u2009.05), while significant differences between the two groups were observed at the interproximal areas (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001 for both CDV and PDI changes). Higher early DTPMs were observed at the TUN\u2010treated sites in terms of mean FI of the graft (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.027) and mean FI (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.024) and pRI of the flap (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.031) compared with CAF\u2010treated sites at 1\u2009week. Assessment of the FI direction showed that CTG perfusion at 1\u2009week and at 1\u2009month mainly occurred from the flap towards the implant\/bone. Early tissue perfusion outcomes were found to be associated with the 12\u2010month mean PSTD coverage and mucosal thickness gain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Doppler ultrasonography shows tissue perfusion changes occurring at implant sites augmented with CTG. The main differences in tissue perfusion between CAF and TUN were observed at the interproximal sites, with early perfusion associated with clinical and volumetric outcomes at 12\u2009months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.13889","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T07:06:52Z","timestamp":1697785612000},"page":"68-79","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Doppler ultrasonographic evaluation of tissue revascularization following connective tissue graft at implant sites"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4864-3964","authenticated-orcid":false,"given":"Lorenzo","family":"Tavelli","sequence":"first","affiliation":[{"name":"Department of Oral Medicine, Infection, and Immunity, Division of Periodontology Harvard School of Dental Medicine  Boston Massachusetts USA"},{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"},{"name":"Center for clinical Research and evidence synthesis In oral TissuE RegeneratION (CRITERION)  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver D.","family":"Kripfgans","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5952-0447","authenticated-orcid":false,"given":"Hsun\u2010Liang","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7320-4878","authenticated-orcid":false,"given":"Maria","family":"Vera Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"},{"name":"Postgraduate Periodontics, Division of Periodontics Columbia University College of Dental Medicine  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamoun","family":"Sabri","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7030-155X","authenticated-orcid":false,"given":"Leonardo","family":"Mancini","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Infection, and Immunity, Division of Periodontology Harvard School of Dental Medicine  Boston Massachusetts USA"},{"name":"Center for clinical Research and evidence synthesis In oral TissuE RegeneratION (CRITERION)  Boston Massachusetts USA"},{"name":"Department of Life, Health and Environmental Sciences University of L'Aquila  L'Aquila Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4238-1799","authenticated-orcid":false,"given":"Hom\u2010Lay","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William V.","family":"Giannobile","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Infection, and Immunity, Division of Periodontology Harvard School of Dental Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5347-6577","authenticated-orcid":false,"given":"Shayan","family":"Barootchi","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Infection, and Immunity, Division of Periodontology Harvard School of Dental Medicine  Boston Massachusetts USA"},{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"},{"name":"Center for clinical Research and evidence synthesis In oral TissuE RegeneratION (CRITERION)  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,20]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12112"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12627"},{"issue":"1","key":"e_1_2_13_4_1","first-page":"14","article-title":"Tunneled coronally advanced flap for the treatment of isolated gingival recessions with deficient papilla","volume":"17","author":"Barootchi S.","year":"2022","journal-title":"International Journal of Esthetic Dentistry"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211035684"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00116.x"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12616"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00660.x"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0301-5629(98)00055-6"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr.20190445"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2005.00777.x"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0215944"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11122289"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2022.104938"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1999.18.8.547"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13156"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-018-1731-9"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2012.10.009"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.22519"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.4.470"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12870"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2016.04.007"},{"key":"e_1_2_13_23_1","volume-title":"Diagnostic ultrasound: Vascular","author":"Lockhart M. E.","year":"2019"},{"key":"e_1_2_13_24_1","volume-title":"Ultrasound physics and instrumentation","author":"Miele F. R.","year":"2022"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2021.02.032"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4042902"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1977.48.11.681"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/JMU.JMU_11_17"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14507"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341262"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12714"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000164145.89275.02"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-6441(09)60114-4"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40477-016-0201-x"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2261-5"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13424"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.21-0402"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13806"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11010008"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019190248"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.21996"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.19.7.076015"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13706"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0616"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12214"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12178"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.13889","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T17:56:45Z","timestamp":1735235805000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.13889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,20]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/jcpe.13889"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.13889","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,20]]},"assertion":[{"value":"2023-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}