{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:50:58Z","timestamp":1791917458860,"version":"4.3.4"},"reference-count":70,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170954"],"award-info":[{"award-number":["82170954"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the relationship between interleukin\u201017 (IL\u201017), ferroptosis and osteogenic differentiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We first analysed the changes in ferroptosis\u2010related molecules in experimental periodontitis models. The effects of erastin, a small\u2010molecule ferroptosis inducer, and IL\u201017 on alveolar bone loss and repair in animal models were then investigated. Primary mouse mandibular osteoblasts were exposed to erastin and IL\u201017 in vitro. Ferroptosis\u2010 and osteogenesis\u2010related genes and proteins were detected. Further, siRNA, immunofluorescence co\u2010localization and immunoprecipitation were used to confirm the roles of the nuclear factor erythroid\u20102\u2010related factor 2 (NRF2) and phosphorylated signal transducer and activator of transcription 3 (p\u2010STAT3), as well as their interaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The levels of NRF2, glutathione peroxidase 4 and solute carrier family 7 member 11 were lower in the ligated tissues than in normal periodontal tissues. Alveolar bone loss in an in vivo experimental periodontitis model was aggravated by erastin and alleviated by IL\u201017. In vitro, IL\u201017 ameliorated erastin\u2010inhibited osteogenic differentiation by reversing ferroptosis. Altered NRF2 expression correlated with changes in ferroptosis\u2010related molecules and osteogenesis. Furthermore, the physical interaction between NRF2 and p\u2010STAT3 was confirmed in the nucleus. In IL\u201017\u2009+\u2009erastin\u2010stimulated osteoblasts, the p\u2010STAT3\u2013NRF2 complex might actively participate in the downstream transcription of ferroptosis\u2010 and osteogenesis\u2010related genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IL\u201017 administration conferred resistance to erastin\u2010induced osteoblast ferroptosis and osteogenesis. The possible mechanism may involve p\u2010STAT3 directly interacting with NRF2.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13898","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T08:39:39Z","timestamp":1699951179000},"page":"233-250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Interleukin\u201017 alleviates erastin\u2010induced alveolar bone loss by suppressing ferroptosis via interaction between <scp>NRF2<\/scp> and <scp>p\u2010STAT3<\/scp>"],"prefix":"10.1111","volume":"51","author":[{"given":"Jiaqi","family":"Bao","sequence":"first","affiliation":[{"name":"Department of Periodontology, The Second Affiliated Hospital, College of Medicine Zhejiang University  Hangzhou China"},{"name":"Cancer Institute The Second Affiliated Hospital of Zhejiang University, School of Medicine  Hangzhou 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