{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T22:17:46Z","timestamp":1789251466198,"version":"build-2803163510"},"reference-count":83,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim of this systematic review was two\u2010fold: (i) to evaluate the long\u2010term (\u22655\u2009years) stability of the gingival margin position, keratinized tissue width (KTW) and gingival thickness (GT) in sites that underwent root coverage (RC) or gingival augmentation (GA); and (ii) to assess the influence of different local variables on the long\u2010term stability of dental and gingival tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Randomized controlled trials (RCTs) and non\u2010RCTs reporting short\u2010term (i.e., 6\u201312\u2009months after baseline surgical intervention) and long\u2010term (\u22655\u2009years) follow\u2010up data after surgical treatment of adult patients presenting single or multiple mucogingival deformities, defined as sites presenting gingival recession defects (GRDs) and\/or (KTW) deficiency (i.e., &lt;2\u2009mm), were considered eligible for inclusion. MEDLINE\u2013PubMed, EMBASE and Cochrane Central Register of Controlled Trials databases were searched for articles published up to 15 May 2023. Mixed\u2010effects multiple linear regression was used to assess the association between KTW, type of surgical procedure and time (i.e., independent variables) on the stability of the gingival margin in sites that received RC or GA therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 2569 potentially eligible records, 41 (reporting 40 studies) met the eligibility criteria. Graphical estimates including data from all RC procedures found an upward trend in recession depth (RD) increase over time. Conversely, it was observed that in 63.63% of RC studies and in 59.32% of RC treatment arms KTW increased over time, particularly in sites treated with subepithelial connective tissue grafts (SCTGs). Conversely, sites that underwent GA procedures generally exhibited an overall reduction of KTW over time. However, sites treated with free gingival grafts (FGGs) showed a decrease in RD after 10\u2009years of follow\u2010up. Three main findings derived from the pooled estimates were identified: (i) Gingival margin stability was associated with the amount of KTW present during short\u2010term assessment (i.e. the greater the KTW at 6\u201312\u2009months after treatment, the more stable the gingival margin). (ii) The use of autogenous soft\u2010tissue grafts was associated with lower RD increase over time. (iii) Treatment approaches that contribute to the three\u2010dimensional enhancement of the gingival phenotype, as clearly demonstrated by FGG, were associated with gingival margin stability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The extent of apical migration of the gingival margin appears to be directly related to the amount of KTW and GT upon tissue maturation. Interventions involving the use of autogenous grafts, either SCTG or FGG, are associated with greater short\u2010term KTW gain and lower RD increase over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.13900","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T18:25:04Z","timestamp":1699986304000},"page":"177-195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Long\u2010term stability of gingival margin and periodontal soft\u2010tissue phenotype achieved after mucogingival therapy: A systematic review"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2275-0437","authenticated-orcid":false,"given":"Ana Claudia","family":"Carbone","sequence":"first","affiliation":[{"name":"Implantology and Periodontology S\u00e3o Leopoldo Mandic Research Institute  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5160-9295","authenticated-orcid":false,"given":"Julio Cesar","family":"Joly","sequence":"additional","affiliation":[{"name":"Implantology and Periodontology S\u00e3o Leopoldo Mandic Research Institute  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1019-8263","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Botelho","sequence":"additional","affiliation":[{"name":"Evidence\u2010Based Hub, Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM) Egas Moniz School of Health &amp; 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