{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:34:37Z","timestamp":1783636477284,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23FA1022"],"award-info":[{"award-number":["23FA1022"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016342","name":"Ministry of Health Mexico","doi-asserted-by":"publisher","award":["21FA1013"],"award-info":[{"award-number":["21FA1013"]}],"id":[{"id":"10.13039\/100016342","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the association between trypsin\u2010like protease (TLP) activity in the oral cavity as an indicator of periodontal health status and kidney function in Japanese workers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This cross\u2010sectional study included 1117 Japanese workers (mean age\u2009=\u200943.8\u2009years). Tongue\u2010swab TLP activity was quantified as <jats:italic>a<\/jats:italic>* value (the redness intensity of the matrix disc of the TLP activity assessment kit; a larger value indicates more intense enzymatic activity in the samples and poorer periodontal health status). Kidney function was assessed using the estimated glomerular filtration rate (eGFR; a lower value indicates poorer kidney function). We performed ordinal logistic regression analyses to assess the association of the <jats:italic>a<\/jats:italic>* value with three eGFR categories: \u226590, 60\u201389 and &lt;60\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence for each eGFR category was as follows: \u226590 (31.6%), 60\u201389 (63.8%) and &lt;60\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup> (4.6%). After adjusting for potential confounders, the <jats:italic>a<\/jats:italic>* value was found to be significantly associated with reduced kidney function. The multivariable\u2010adjusted odds ratio (95% confidence interval) for reduced kidney function was 1.12 (1.02\u20131.22) per unit increase in the <jats:italic>a<\/jats:italic>* value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Higher TLP activity was associated with reduced kidney function in Japanese workers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13908","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T05:14:56Z","timestamp":1701234896000},"page":"265-273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The association between trypsin\u2010like protease activity in the oral cavity and kidney function in Japanese workers"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5739-2936","authenticated-orcid":false,"given":"Masanori","family":"Iwasaki","sequence":"first","affiliation":[{"name":"Dental Center 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