{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:04:57Z","timestamp":1791309897759,"version":"4.3.1"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002152","name":"International Trachoma Initiative","doi-asserted-by":"publisher","award":["2021\u20101612"],"award-info":[{"award-number":["2021\u20101612"]}],"id":[{"id":"10.13039\/100002152","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030982","name":"Straumann Group","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030982","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019921","name":"Geistlich Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the impact of the timing of implant placement following alveolar ridge preservation (ARP) on the need for soft\u2010tissue augmentation (STA) and to identify the risk factors for horizontal and vertical soft\u2010tissue loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Patients with a single failing tooth in the anterior maxilla (15\u201325) were treated at six centres. Following tooth extraction, they were randomly allocated to the test group (immediate implant placement, IIP) or control group (delayed implant placement, DIP). ARP was performed in both groups and implants were immediately restored with an implant\u2010supported provisional crown. Six months after tooth extraction and ARP, a panel of five blinded clinicians assessed the need for STA on the basis of anonymized clinical pictures and a digital surface model. Lack of buccal soft\u2010tissue convexity and\/or mid\u2010facial recession qualified for STA. Pre\u2010operative and 6\u2010month digital surface models were superimposed to assess horizontal and vertical soft\u2010tissue changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty patients were included per group (test: 20 females, 10 males, mean age 53.1; control: 15 females, 15 males, mean age 59.8). The panel deemed STA as necessary in 24.1% and 35.7% of the cases following IIP and DIP, respectively. The difference was not statistically significant (odds ratio [OR]\u2009=\u20091.77; 95% confidence interval [CI] [0.54\u20135.84]; <jats:italic>p<\/jats:italic>\u2009=\u2009.343). Loss of buccal soft\u2010tissue profile was higher following DIP (estimated mean ratio\u2009=\u20091.66; 95% CI [1.10\u20132.52]; <jats:italic>p<\/jats:italic>\u2009=\u2009.018), as was mid\u2010facial recession (mean difference [MD]\u2009=\u20090.47\u2009mm; 95% CI [0.12\u20130.83]; <jats:italic>p<\/jats:italic>\u2009=\u2009.011). Besides DIP, regression analysis identified soft\u2010tissue thickness (\u22120.57; 95% CI [\u22121.14 to \u22120.01]; <jats:italic>p<\/jats:italic>\u2009=\u2009.045) and buccal bone dehiscence (0.17; 95% CI [0.01\u20130.34]; <jats:italic>p<\/jats:italic>\u2009=\u2009.045) as additional risk factors for mid\u2010facial recession. Surgeons found IIP significantly more difficult than DIP (visual analogue scale MD\u2009=\u2009\u221234.57; 95% CI [\u221248.79 to \u221220.36]; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This multi\u2010centre randomized controlled trial failed to demonstrate a significant difference in the need for STA between IIP and DIP when judged by a panel of blinded clinicians. Based on objective soft\u2010tissue changes, patients with thin buccal soft tissues, with a buccal bone dehiscence and treated with a delayed approach appeared particularly prone to soft\u2010tissue loss.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13911","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T21:49:24Z","timestamp":1702417764000},"page":"1644-1655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A multi\u2010centre randomized controlled trial on alveolar ridge preservation with immediate or delayed implant placement: Need for soft\u2010tissue augmentation"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5042-2875","authenticated-orcid":false,"given":"Jan","family":"Cosyn","sequence":"first","affiliation":[{"name":"Department of Periodontology and Oral Implantology, Faculty of Medicine and Health Sciences, Oral Health Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1547-057X","authenticated-orcid":false,"given":"Lorenz","family":"Seyssens","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Implantology, Faculty of Medicine and Health Sciences, Oral Health Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"De Bruyckere","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Implantology, Faculty of Medicine and Health Sciences, Oral Health Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"De Buyser","sequence":"additional","affiliation":[{"name":"Biostatistics Unit, Faculty of Medicine and Health Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1754-9588","authenticated-orcid":false,"given":"Andrej","family":"Djurkin","sequence":"additional","affiliation":[{"name":"IMDS\u2010Institut de M\u00e9decine Dentaire et de Stomatologie Cliniques Universitaires Saint Luc Universit\u00e9 catholique de Louvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1515-8965","authenticated-orcid":false,"given":"Aryan","family":"Eghbali","sequence":"additional","affiliation":[{"name":"Private Practice Ortho Paro Care  Meise Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me Fr\u00e9d\u00e9ric","family":"Lasserre","sequence":"additional","affiliation":[{"name":"IMDS\u2010Institut de M\u00e9decine Dentaire et de Stomatologie Cliniques Universitaires Saint Luc Universit\u00e9 catholique de Louvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Tudts","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Implantology, Faculty of Medicine and Health Sciences, Oral Health Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3716-5119","authenticated-orcid":false,"given":"Faris","family":"Younes","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Implantology, Faculty of Medicine and Health Sciences, Oral Health Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selena","family":"Toma","sequence":"additional","affiliation":[{"name":"IMDS\u2010Institut de M\u00e9decine Dentaire et de Stomatologie Cliniques Universitaires Saint Luc Universit\u00e9 catholique de Louvain  Brussels 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