{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:33:12Z","timestamp":1791379992989,"version":"4.3.3"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173647"],"award-info":[{"award-number":["82173647"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970536"],"award-info":[{"award-number":["81970536"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>CCR2 (C\u2010C chemokine receptor type 2) plays a crucial role in inflammatory and bone metabolic diseases; however, its role in peri\u2010implantitis remains unclear. This study aimed to explore whether CCR2 contributes to peri\u2010implantitis and the treatment effects of cenicriviroc (CVC) on peri\u2010implant inflammation and bone resorption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The expression of CCR2 was studied using clinical tissue analysis and an in vivo peri\u2010implantitis model. The role of CCR2 in promoting inflammation and bone resorption in peri\u2010implantitis was evaluated in <jats:italic>Ccr2<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> mice and wild\u2010type mice. The effect of CVC on peri\u2010implantitis was evaluated using systemic and local dosage forms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Human peri\u2010implantitis tissues showed increased CCR2 and CCL2 levels, which were positively correlated with bone loss around the implants. Knocking out Ccr2 in an experimental model of peri\u2010implantitis resulted in decreased monocyte and macrophage infiltration, reduced pro\u2010inflammatory cytokine generation and impaired osteoclast activity, leading to reduced inflammation and bone loss around the implants. Treatment with CVC ameliorated bone loss in experimental peri\u2010implantitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CCR2 may be a potential target for peri\u2010implantitis treatment by harnessing the immune\u2010inflammatory response to modulate the local inflammation and osteoclast activity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13916","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T08:58:45Z","timestamp":1702976325000},"page":"354-364","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["<scp>CCR2<\/scp> is a potential therapeutic target in peri\u2010implantitis"],"prefix":"10.1111","volume":"51","author":[{"given":"Shasha","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Periodontology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology 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