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Molecular docking was used to investigate the binding affinity of Cur for the predicted targets. A mouse model with ligature\u2010induced periodontitis (LIP) was used to verify the therapeutic effect of Cur. Microcomputed tomography (micro\u2010CT) was used to evaluate alveolar bone resorption, while western blotting, haematoxylin\u2013eosin staining and immunohistochemistry were used to analyse the change in immunopathology. SYTOX Green staining was used to assess the in vitro effect of Cur in a mouse bone marrow\u2010isolated neutrophil model exposed to lipopolysaccharide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Network pharmacology identified 114 potential target genes. Enrichment analysis showed that Cur can modulate the production of neutrophil extracellular traps (NETs). Molecular docking experiments suggested that Cur effectively binds to neutrophil elastase (ELANE), peptidylarginine deiminase 4 (PAD4) and cathepsin G, three enzymes involved in NETs. In LIP mice, Cur alleviated alveolar bone resorption and reduced the expression of ELANE and PAD4 in a time\u2010dependent but dose\u2010independent manner. Cur can directly inhibit NET formation in the cell model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our research suggested that Cur may alleviate experimental periodontitis by inhibiting NET formation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13962","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T10:01:32Z","timestamp":1707818492000},"page":"787-799","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Computational analysis of curcumin\u2010mediated alleviation of inflammation in periodontitis patients with experimental validation in mice"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4983-2241","authenticated-orcid":false,"given":"Danfeng","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, College of Stomatology Chongqing Medical University  Chongqing 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