{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:35:26Z","timestamp":1791941726409,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271004"],"award-info":[{"award-number":["82271004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to reveal the unique microenvironment of peri\u2010implantitis through single\u2010cell analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Herein, we performed single\u2010cell RNA sequencing (scRNA\u2010seq) of biopsies from patients with peri\u2010implantitis (PI) and compared the results with healthy individuals (H) and patients with periodontitis (PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Decreased numbers of stromal cells and increased immune cells were found in the PI group, which implies a severe inflammatory infiltration. The fibroblasts were found to be heterogeneous and the specific pro\u2010inflammatory CXCL13\n                      <jats:sup>+<\/jats:sup>\n                      sub\u2010cluster was more represented in the PI group, in contrast to the PD and H groups. Furthermore, more neutrophil infiltration was detected in the PI group than in the PD group, and cell\u2013cell communication and ligand\u2013receptor pairs revealed most neutrophils were recruited by CXCL13\n                      <jats:sup>+<\/jats:sup>\n                      fibroblasts through CXCL8\/CXCL6\u2010CXCR2\/CXCR1. Notably, our study demonstrated that the unique microenvironment of the PI group promoted the differentiation of monocyte\/macrophage lineage cells into osteoclasts, which might explain the faster and more severe bone resorption in the progression of PI than PD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Collectively, this study suggests a unique immune microenvironment of PI, which may explain the differences between PI and PD in the clinic. These outcomes will aid in finding new specific and effective treatments for PI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.13982","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T02:14:00Z","timestamp":1712110440000},"page":"1665-1676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Single\u2010cell analysis reveals a unique microenvironment in peri\u2010implantitis"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2265-8084","authenticated-orcid":false,"given":"J.","family":"Li","sequence":"first","affiliation":[{"name":"Department of Second Dental Center, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University  Shanghai China"},{"name":"National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. J.","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Second Dental Center, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University  Shanghai China"},{"name":"National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. W.","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Second Dental Center, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University  Shanghai China"},{"name":"National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. W.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Second Dental Center, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University  Shanghai China"},{"name":"National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Second Dental Center, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University  Shanghai China"},{"name":"National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. H.","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Second Dental Center, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University  Shanghai China"},{"name":"National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Second Dental Center, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University  Shanghai China"},{"name":"National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q. G.","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Second Dental Center, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University  Shanghai China"},{"name":"National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology  Shanghai China"},{"name":"Department of Stomatology, Zhang Zhiyuan Academician Work Station Hainan, Western Central Hospital  Danzhou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. Q.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Second Dental Center, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University  Shanghai China"},{"name":"National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0739"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01672.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12067"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514551754"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.65694"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01277.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.52"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513504950"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.5037\/jomr.2016.7315"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13370"},{"key":"e_1_2_11_12_1","article-title":"Interventions for replacing missing teeth: Treatment of peri\u2010implantitis","volume":"1","author":"Esposito M.","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13056"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12852"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041-1014.2012.00663.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.10.082"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.88183.3"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12372"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034519853574"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13496"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12718"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515622432"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s10038-020-00844-3"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2021.100953"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12124"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13287"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516667484"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.778078"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.795441"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12777"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21350"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368917X694831"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.05.013"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-020-00356-1"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.13982","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T20:33:51Z","timestamp":1737318831000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.13982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,2]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/jcpe.13982"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.13982","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,2]]},"assertion":[{"value":"2023-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}