{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:01:41Z","timestamp":1783350101505,"version":"3.54.6"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the potential benefits of minimally invasive non\u2010surgical therapy (MINST) in teeth with intrabony defects and to explore factors associated with the outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A multi\u2010centre trial was conducted in 100 intrabony defects in periodontitis patients in private practice. Steps 1 and 2 periodontal therapy including MINST were provided. Clinical and radiographic data were analysed at baseline and 12\u2009months after treatment, with the primary aim being change in radiographic defect depth at 12\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010four patients completed the 12\u2010month follow up. The mean total radiographic defect depth reduced by 1.42\u2009mm and the defect angle increased by 3\u00b0 (both <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Statistically significant improvements in probing pocket depth (PPD) and clinical attachment level (CAL) were seen at 12\u2009months compared to baseline (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Fifty\u2010six defects (66.7%) achieved pocket closure (PPD\u2009\u2264\u20094\u2009mm) and 49 defects (58.3%) achieved the composite outcome (PPD\u2009\u2264\u20094\u2009mm and CAL gain \u22653\u2009mm). Deeper and narrower angled defects were positively correlated with radiographic and clinical improvements, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Improvements in clinical and radiographic outcomes were seen after MINST. This study highlights the generalizability and wide applicability of this approach, further supporting its effectiveness in the treatment of intrabony defects. Clinical trial registration: NCT03741374. <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT03741374?cond=minimally%20invasive%20non%20surgical%20therapy%26locStr=UK%26country=United%20Kingdom%26distance=50%26rank=2\">https:\/\/clinicaltrials.gov\/study\/NCT03741374?cond=minimally%20invasive%20non%20surgical%20therapy&amp;locStr=UK&amp;country=United%20Kingdom&amp;distance=50&amp;rank=2<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13984","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T01:09:58Z","timestamp":1715044198000},"page":"905-914","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Minimally invasive non\u2010surgical periodontal therapy of intrabony defects: A prospective multi\u2010centre cohort study"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2804-7356","authenticated-orcid":false,"given":"Jaimini","family":"Mehta","sequence":"first","affiliation":[{"name":"Periodontology Unit, Centre for Host Microbiome Interactions, Faculty of Dentistry Oral &amp; Craniofacial Sciences, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7312-802X","authenticated-orcid":false,"given":"Marco","family":"Montevecchi","sequence":"additional","affiliation":[{"name":"Division of Periodontology and Implantology, Department of Biomedical and Neuromotor Sciences School of Dentistry and Dental Hygiene, University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Garcia\u2010Sanchez","sequence":"additional","affiliation":[{"name":"Periodontology Unit, Centre for Host Microbiome Interactions, Faculty of Dentistry Oral &amp; 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