{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:40:40Z","timestamp":1792471240035,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T00:00:00Z","timestamp":1714867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the changes in periodontal parameters (reduction in probing pocket depth [PPD], gain in clinical attachment level [CAL] and reduction in full\u2010mouth bleeding on probing [BoP]) after subgingival instrumentation of periodontal pockets at different time points in systemically healthy patients suffering from periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Four databases were searched for RCTs that carried out subgingival instrumentation in periodontal pockets and evaluated PPD at a minimum of two consecutive time points other than baseline. The analysis was conducted for both all pocket depths and stratified for initially shallow (4\u20135\u2009mm) and deep (\u22656\u2009mm) pockets and data were extracted for various time points, 1\u20132, 3\u20134 and 5\u20136\u2009months. Weighted mean effects (WMEs) were calculated with 95% confidence interval (CI) and predictive intervals were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010nine RCTs were identified, and all of them were included in the meta\u2010analysis. The results showed that for both shallow and deep pockets there was a small though clinically meaningful change between 1\u2010 to 2\u2010month and 3\u2010 to 4\u2010month time points and between these and 5\u20136\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In systemically healthy patients, the greater part of reduction in PPD and gain in CAL occurs within the first 1\u20132\u2009months after subgingival instrumentation. However, additional benefits in terms of pocket depth reduction occur beyond these early time points.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13985","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T05:48:53Z","timestamp":1714974533000},"page":"137-158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Change in clinical parameters after subgingival instrumentation for the treatment of periodontitis and timing of periodontal re\u2010evaluation: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1397-0984","authenticated-orcid":false,"given":"Lucrezia","family":"Patern\u00f2 Holtzman","sequence":"first","affiliation":[{"name":"Department of Periodontology and Prosthodontics George Eastman Dental Hospital, Policlinico Universitario Umberto I  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1403-5274","authenticated-orcid":false,"given":"Nicola Alberto","family":"Valente","sequence":"additional","affiliation":[{"name":"Division of Periodontology, School of Dental Medicine, Department of Surgical Sciences Faculty of Medicine, Universit\u00e0 degli Studi di Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9819-8199","authenticated-orcid":false,"given":"Gianluca","family":"Vittorini Orgeas","sequence":"additional","affiliation":[{"name":"Department of Periodontology Universit\u00e0 Cattolica del Sacro Cuore School of Dentistry  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Copes","sequence":"additional","affiliation":[{"name":"Department of Periodontology Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1805-2899","authenticated-orcid":false,"given":"Nicola","family":"Discepoli","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, Unit of Periodontology University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1827-5200","authenticated-orcid":false,"given":"Marco","family":"Clementini","sequence":"additional","affiliation":[{"name":"UniCamillus\u2010Saint Camillus International University of Health Sciences  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,5]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2019.01.006"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.170165"},{"key":"e_1_2_13_4_1","doi-asserted-by":"crossref","unstructured":"Armitage G. 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