{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:02:43Z","timestamp":1790787763642,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Treatment of periodontitis, a chronic inflammatory disease driven by biofilm dysbiosis, remains challenging due to patients' poor performance and adherence to the necessary oral hygiene procedures. Novel, artificial intelligence\u2010enabled multimodal\u2010sensing toothbrushes (AI\u2010MST) can guide patients' oral hygiene practices in real\u2010time and transmit valuable data to clinicians, thus enabling effective remote monitoring and guidance. The aim of this trial was to assess the effect of such a system as an adjunct to clinical practice guideline\u2010conform treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This was a single\u2010centre, double\u2010blind, standard\u2010of\u2010care controlled, randomized, parallel\u2010group, superiority trial. Male and female adults with generalized Stage II\/III periodontitis were recruited at the Shanghai Ninth People's Hospital, China. Subjects received a standard\u2010of\u2010care oral hygiene regimen or a technology\u2010enabled, theory\u2010based digital intervention consisting of an AI\u2010MST and targeted doctor's guidance by remote micromessaging. Additionally, both groups received guideline\u2010conform periodontal treatment. The primary outcome was the resolution of inflamed periodontal pockets (\u22654\u2009mm with bleeding on probing) at 6\u2009months. The intention\u2010to\u2010treat (ITT) analysis included all subjects who received the allocated treatment and at least one follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred patients were randomized and treated (50 tests\/controls) between 1 February and 30 November 2022. Forty\u2010eight tests (19 females) and 47 controls (16 females) were analysed in the ITT population. At 6\u2009months, the proportion of inflamed periodontal pockets decreased from 80.7% (95% confidence interval [CI] 76.5\u201384.8) to 52.3% (47.7\u201357.0) in the control group, and from 81.4% (77.1\u201385.6) to 44.4% (39.9\u201348.9) in the test group. The inter\u2010group difference was 7.9% (1.6\u201314.6, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Test subjects achieved better levels of oral hygiene (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). No significant adverse events were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The tested digital health intervention significantly improved the outcome of periodontal therapy by enhancing the adherence and performance of self\u2010performed oral hygiene. The model breaks the traditional model of oral health care and has the potential to improve efficiency and reduce costs (NCT05137392).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13987","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T23:34:30Z","timestamp":1713396870000},"page":"1632-1643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Enhanced control of periodontitis by an artificial intelligence\u2010enabled multimodal\u2010sensing toothbrush and targeted <scp>mHealth<\/scp> micromessages: A randomized trial"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0133-7516","authenticated-orcid":false,"given":"Yuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Implantology, Shanghai PerioImplant Innovation Center Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine 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