{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T14:20:49Z","timestamp":1775744449523,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:00:00Z","timestamp":1712966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016149","name":"Seoul National University Dental Hospital","doi-asserted-by":"publisher","award":["04\u20102020\u20100107"],"award-info":[{"award-number":["04\u20102020\u20100107"]}],"id":[{"id":"10.13039\/501100016149","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study investigated the adjunctive effect of polydeoxyribonucleotide (PDRN) on bone formation in alveolar ridge preservation (ARP) sockets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Both mandibular second, third and fourth premolars of eight beagle dogs were randomly divided into ARP and ARP\/PDRN groups. Following tooth extraction, ARP procedures were conducted using collagenized alloplastic graft material and bilayer collagen membrane soaked with normal saline (ARP group) or PDRN (ARP\/PDRN group) for 10\u2009min before application. Both groups were also randomly allocated to 2\u2010, 4\u2010 or 12\u2010week healing subgroups. The primary endpoint of this study was to compare histomorphometric differences between ARP and ARP\/PDRN. The secondary endpoints of this study were to compare micro\u2010CT analysis and three\u2010dimensional volumetric measurement between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the histomorphometric analysis, the ARP\/PDRN group exhibited greater new bone formation at coronal, middle and total position compared with the ARP group at 2\u2010week healing. The number of newly formed blood vessels was higher in the ARP\/PDRN group than in the ARP group at 2\u2010 and 4\u2010week healing. In micro\u2010CT analysis, the mean new bone volume\/total bone volume between ARP and ARP\/PDRN was statistically significant at 2\u2010week healing. Ridge volume alterations were significantly decreased in the ARP\/PDRN group during entire healing time compared with the ARP group, especially on the buccal side.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The application of PDRN in ARP might provide additional benefits for early bone regeneration and maintenance of buccal ridge volume.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13988","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T08:54:26Z","timestamp":1712998466000},"page":"1034-1043","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The adjunctive effect of polydeoxyribonucleotide on bone formation in alveolar ridge preservation: A pre\u2010clinical in vivo study"],"prefix":"10.1111","volume":"51","author":[{"given":"Young\u2010Chang","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Periodontology, School of Dentistry and Dental Research Institute Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5508-442X","authenticated-orcid":false,"given":"Jungwon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry and Dental Research Institute Seoul National University  Seoul Republic of Korea"},{"name":"One\u2010Stop Specialty Center Seoul National University Dental Hospital  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istvan","family":"Urban","sequence":"additional","affiliation":[{"name":"Division of Periodontology, Department of Oral Medicine, Infection, and Immunity Harvard School of Dental Medicine  Boston Massachusetts USA"},{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"},{"name":"Department of Periodontology University of Szeged  Szeged Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang\u2010Jo","family":"Seol","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry and Dental Research Institute Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Moo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry and Dental Research Institute Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9809-2630","authenticated-orcid":false,"given":"Ki\u2010Tae","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry and Dental Research Institute Seoul National University  Seoul Republic of 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