{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:24:20Z","timestamp":1784546660132,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T00:00:00Z","timestamp":1716076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE019456"],"award-info":[{"award-number":["R01DE019456"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to compare microbial and inflammatory profiles in periodontally\/systemically healthy African American (AA) and Caucasian (C) individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Thirty\u2010seven C and 46 AA aged from 5 to 25\u2009years were evaluated regarding periodontal disease, caries, microbial subgingival profile via 16\u2010s sequencing, as well as salivary and gingival crevicular fluid (GCF) inflammatory profile via multiplex assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Greater probing depth percentage was detected in AA (<jats:italic>p<\/jats:italic>\u2009=\u2009.0075), while a higher percentage of caries index (<jats:italic>p<\/jats:italic>\u2009=\u2009.0069) and decayed, missing, filled teeth (DMFT) index (<jats:italic>p<\/jats:italic>\u2009=\u2009.0089) was observed in C, after adjusting for number of teeth, sex and age. Salivary levels of IL\u20106, IL\u20108 and TNF\u03b1 were higher for C, whereas GCF levels of eotaxin, IL\u201012p40, IL\u201012p70, IL\u20102 and MIP\u20101\u03b1 were higher in AA (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Different microbial profiles were observed between the races (<jats:italic>p<\/jats:italic>\u2009=\u2009.02). AA presented higher abundance of periodontopathogens (such as <jats:italic>Tanerella forsythia<\/jats:italic>, <jats:italic>Treponema denticola<\/jats:italic>, <jats:italic>Filifactor alocis<\/jats:italic>, among others), and C presented more caries\u2010associated bacteria (such as <jats:italic>Streptococcus mutans<\/jats:italic> and <jats:italic>Prevotella<\/jats:italic> species). <jats:italic>Bacillaceae<\/jats:italic> and <jats:italic>Lactobacillus<\/jats:italic> species were associated with higher DMFT index, whereas <jats:italic>Fusobacterium<\/jats:italic> and <jats:italic>Tanerella<\/jats:italic> species with periodontal disease parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A different inflammatory and bacterial profile was observed between healthy AA and C, which may predispose these races to higher susceptibility to specific oral diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13989","type":"journal-article","created":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T23:30:15Z","timestamp":1716161415000},"page":"895-904","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Periodontal inflammatory and microbial profiles in healthy young African Americans and Caucasians"],"prefix":"10.1111","volume":"51","author":[{"given":"Samer","family":"Sabbagh","sequence":"first","affiliation":[{"name":"Department of Oral Health Practice, Periodontology Division, College of Dentistry University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reuben","family":"Adatorwovor","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, College of Public Health University of Kentucky  Lexington Kentucky 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