{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:36:44Z","timestamp":1788561404311,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the bidirectional influence between periodontitis and psoriasis, using the respective experimental models of ligature\u2010 and imiquimod\u2010induced diseases on murine models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Thirty\u2010two C57\/BL6J mice were randomly allocated to four experimental groups: control (P\u2212 Pso\u2212), ligature\u2010induced periodontitis (P+\u2009Pso\u2212), imiquimod\u2010induced psoriasis (P\u2212 Pso+) and periodontitis and psoriasis (P+\u2009Pso+). Samples (maxilla, dorsal skin and blood) were harvested immediately after death. Measures of periodontitis (distance between the cemento\u2010enamel junction and alveolar bone crest [CEJ\u2013ABC] and the number of osteoclasts) and psoriasis (epidermal thickness and infiltrate cell [\/0.03mm<jats:sup>2<\/jats:sup>]) severity as well as systemic inflammation (IL\u20106, IL\u201017A, TNF\u2010\u03b1) were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The P+\u2009Pso+\u2009group exhibited the most severe experimental periodontitis and psoriasis, with the highest values of CEJ\u2013ABC, number of osteoclasts, epidermal thickness and infiltrate cells in the dorsal skin, as well as the highest blood cytokine concentration. The P+\u2009Pso\u2212 group presented with higher cell infiltrate (\/0.03mm<jats:sup>2<\/jats:sup>) compared to the control group (<jats:italic>p<\/jats:italic>\u2009&lt;.05), while the P\u2212 Pso+\u2009group showed substantially higher alveolar bone loss (CEJ\u2013ABC) than the control group (<jats:italic>p<\/jats:italic>\u2009&lt;.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Experimental periodontitis may initiate and maintain psoriasiform skin inflammation and, vice versa, experimental psoriasis may contribute to the onset of periodontitis. In a combined model of the diseases, we propose a bidirectional association between periodontitis and psoriasis via systemic inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13996","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T08:29:41Z","timestamp":1714724981000},"page":"1044-1053","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Are periodontitis and psoriasis associated? 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