{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:14:10Z","timestamp":1790129650669,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To retrospectively compare two approaches for the adjunctive use of systemic antibiotics in non\u2010surgical periodontal therapy: one based on the detection of <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> (Aa) and the other on age and severity of periodontitis (Age &amp; PPD). We also assessed the additional benefit of antibiotics in reducing the need for further surgical therapy in each group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Patients of the Department of Periodontology, Goethe University Frankfurt, Germany, were screened for microbiological testing between 2008 and 2018. Patients were categorized by their microbiological result (Aa+\/\u2212) and demographic\/clinical data (Age &amp; PPD+\/\u2212). Agreement on antibiotic indication was tested. The clinical evaluation focussed on teeth with probing pocket depths (PPDs)\u2009\u2265\u20096\u2009mm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analysis of 425 patients revealed 30% categorized as Age &amp; PPD+ and 34% as Aa+. Sixty\u2010three percent had consistent antibiotic recommendations (phi coefficient 0.14, <jats:italic>p<\/jats:italic>\u2009=\u2009.004). Patients in the Age &amp; PPD+ group receiving antibiotics showed the most substantial reduction in the number of teeth with PPD\u2009\u2265\u20096\u2009mm after non\u2010surgical periodontal therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both strategies resulted in a significant clinical improvement compared with those without antibiotic treatment and restricted antibiotic use similarly, but targeted different patient groups. Younger individuals with severe periodontitis benefited most from antibiotics, reducing the need for additional surgeries. The study was registered in an international trial register (German Clinical Trial Register number DRKS00028768, registration date 27 April 2022, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/drks.de\/search\/en\/trial\/DRKS00028768\">https:\/\/drks.de\/search\/en\/trial\/DRKS00028768<\/jats:ext-link>).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.14003","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T08:46:33Z","timestamp":1717404393000},"page":"1122-1133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Decision\u2010making on systemic antibiotics in the management of periodontitis: A retrospective comparison of two concepts"],"prefix":"10.1111","volume":"51","author":[{"given":"Patrizia C.","family":"Winkler","sequence":"first","affiliation":[{"name":"Department of Periodontology Center for Dentistry and Oral Medicine (Carolinum), Goethe University Frankfurt\/Main  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leander","family":"Benz","sequence":"additional","affiliation":[{"name":"Department of Periodontology Center for Dentistry and Oral Medicine (Carolinum), Goethe University Frankfurt\/Main  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3785-8364","authenticated-orcid":false,"given":"Katrin","family":"Nickles","sequence":"additional","affiliation":[{"name":"Department of Periodontology Center for Dentistry and Oral Medicine (Carolinum), Goethe University Frankfurt\/Main  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8901-8017","authenticated-orcid":false,"given":"Hari C.","family":"Petsos","sequence":"additional","affiliation":[{"name":"Department of Periodontology Center for Dentistry and Oral Medicine (Carolinum), Goethe University Frankfurt\/Main  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1655-8055","authenticated-orcid":false,"given":"Peter","family":"Eickholz","sequence":"additional","affiliation":[{"name":"Department of Periodontology Center for Dentistry and Oral Medicine (Carolinum), Goethe University Frankfurt\/Main  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1054-0479","authenticated-orcid":false,"given":"Bettina","family":"Dannewitz","sequence":"additional","affiliation":[{"name":"Department of Periodontology Center for Dentistry and Oral Medicine (Carolinum), Goethe University Frankfurt\/Main  Frankfurt Germany"},{"name":"Private Dental Practice  Weilburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.43.11.5721-5732.2005"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01795.x"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_13_5_1","first-page":"263","article-title":"Adjuvantive Antibiotikagabein der Parodontitistherapie. 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