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The HIIT protocol, involving daily treadmill sessions, spanned 8\u2009weeks, with PD induced by ligature after the 6th week. Behavioural tests were conducted to assess anxiety and memory. Post euthanasia, we evaluated the systemic inflammatory profile and oxidative stress markers in the hippocampus and amygdala. A morphological evaluation and elemental composition analysis of the mandibular alveolar bone were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PD exacerbated alveolar bone level, bone surface damage and alterations in calcium and phosphorus percentages on the bone surface (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05), while HIIT attenuated these changes (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). HIIT improved systemic inflammatory markers altered by PD (tumour necrosis factor [TNF]\u2010\u03b1, interleukin [IL]\u201010, TNF\u2010\u03b1\/IL\u201010 and IL\u20101\u03b2\/IL\u201010 ratios, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). PD animals exhibited lower total antioxidant capacity and levels of thiobarbituric acid reactive substances in the amygdala and hippocampus, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). HIIT maintained these parameters at levels similar to those in NT animals. HIIT improved anxiety and memory outcomes altered by PD (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HIIT attenuates systemic inflammation, anxiety and memory outcomes promoted by PD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.14020","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T06:10:00Z","timestamp":1716790200000},"page":"1222-1235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["High\u2010intensity interval training mitigates the progression of periodontitis and improves behavioural aspects in rats"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6971-2366","authenticated-orcid":false,"given":"Ramona Ramalho de Souza","family":"Pereira","sequence":"first","affiliation":[{"name":"Health Sciences Program Universidade Federal dos Vales do Jequitinhonha e 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