{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:11:41Z","timestamp":1788833501248,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this analysis was to compare a clinical periodontal prognostic system and a developed and externally validated artificial intelligence (AI)\u2010based model for the prediction of tooth loss in periodontitis patients under supportive periodontal care (SPC) for 10\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Clinical and radiographic parameters were analysed to assign tooth prognosis with a tooth prognostic system (TPS) by two calibrated examiners from different clinical centres (London and Pittsburgh). The prediction model was developed on the London dataset. A logistic regression model (LR) and a neural network model (NN) were developed to analyse the data. These models were externally validated on the Pittsburgh dataset. The primary outcome was 10\u2010year tooth loss in teeth assigned with \u2018unfavourable\u2019 prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1626 teeth in 69 patients were included in the London cohort (development cohort), while 2792 teeth in 116 patients were included in the Pittsburgh cohort (external validated dataset). While the TPS in the validation cohort exhibited high specificity (99.96%), moderate positive predictive value (PPV\u2009= 50.0%) and very low sensitivity (0.85%), the AI\u2010based model showed moderate specificity (NN\u2009=\u200952.26%, LR\u2009=\u200967.59%), high sensitivity (NN\u2009=\u200998.29%, LR\u2009=\u200991.45%), and high PPV (NN\u2009=\u200989.1%, LR\u2009=\u200988.6%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AI\u2010based models showed comparable results with the clinical prediction model, with a better performance in specific prognostic risk categories, confirming AI prediction model as a promising tool for the prediction of tooth loss.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.14023","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T04:28:25Z","timestamp":1723004905000},"page":"1333-1341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Exploring the accuracy of tooth loss prediction between a clinical periodontal prognostic system and a machine learning prognostic model"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4102-1759","authenticated-orcid":false,"given":"Pasquale","family":"Santamaria","sequence":"first","affiliation":[{"name":"Periodontology Unit, Centre for Host\u2010Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5647-4414","authenticated-orcid":false,"given":"Giuseppe","family":"Troiano","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2081-6651","authenticated-orcid":false,"given":"Matteo","family":"Serroni","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Periodontology Unit, Innovative Technologies in Medicine &amp; Dentistry Department University \"G. D'annunzio\" of Chieti\u2010Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago G.","family":"Ara\u00f9jo","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3029-8130","authenticated-orcid":false,"given":"Andrea","family":"Ravid\u00e0","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7750-5010","authenticated-orcid":false,"given":"Luigi","family":"Nibali","sequence":"additional","affiliation":[{"name":"Periodontology Unit, Centre for Host\u2010Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13692"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7594"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520903725"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11113189"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01743.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070551"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20-0855"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070210"},{"issue":"1","key":"e_1_2_11_10_1","first-page":"3","article-title":"Periodontal diagnosis in daily practice","volume":"45","author":"Lang N. 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