{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T12:13:27Z","timestamp":1792325607914,"version":"4.4.0"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this retrospective long\u2010term follow\u2010up of a 3\u2010month RCT was to assess whether non\u2010surgical peri\u2010implantitis treatment with adjunctive systemic antibiotics influenced the need for additional surgical treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Patients enrolled in an aftercare programme following non\u2010surgical peri\u2010implantitis treatment, with or without systemic amoxicillin and metronidazole, were analysed. Data had previously been collected pre\u2010treatment (T<jats:sub>0<\/jats:sub>) and 3\u2009months after treatment (T<jats:sub>1<\/jats:sub>) and were additionally collected during subsequent aftercare visits, until the final assessment (T<jats:sub>2<\/jats:sub>). Primary outcome was the need for additional surgical peri\u2010implantitis therapy during the aftercare programme, analysed via Kaplan\u2013Meier analysis and Cox regression. Secondary outcomes involved clinical parameters, assessed using parametric and non\u2010parametric tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010five patients (22 AB\u2212 group, 23 AB+ group) were included. The mean follow\u2010up time between T<jats:sub>1<\/jats:sub> and T<jats:sub>2<\/jats:sub> was 35.9\u2009months (SD\u2009=\u200921.0). 73.9% of the AB+ group and 50.0% of the AB\u2212 group did not receive additional surgical therapy (log\u2010rank test, <jats:italic>p<\/jats:italic>\u2009=\u2009.110). The adjusted Cox regression model did not provide a significant result for antibiotics (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009.441, 95% CI\u2009=\u20090.159\u20131.220, <jats:italic>p<\/jats:italic>\u2009=\u2009.115). Univariable regression analysis highlighted the influence of baseline peri\u2010implant pocket depth on the need for surgical treatment (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20091.446, 95% CI\u2009=\u20091.035\u20132.020, <jats:italic>p<\/jats:italic>\u2009=\u2009.031).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Systemic amoxicillin and metronidazole administered during non\u2010surgical peri\u2010implantitis treatment do not seem to prevent the need for additional surgical therapy in the long term, during a structured aftercare programme.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.14024","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T10:50:16Z","timestamp":1717498216000},"page":"997-1004","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Do systemic amoxicillin and metronidazole during the non\u2010surgical peri\u2010implantitis treatment phase prevent the need for future surgical treatment? A retrospective long\u2010term cohort study"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6991-7218","authenticated-orcid":false,"given":"Jarno","family":"Hakkers","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Medical Center Groningen and University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tine E.","family":"Vangsted","sequence":"additional","affiliation":[{"name":"Parodontologische Kliniek Den Haag  The Hague The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arie Jan","family":"van Winkelhoff","sequence":"additional","affiliation":[{"name":"Center for Dentistry and Oral Hygiene, University Medical Center Groningen and University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5638-462X","authenticated-orcid":false,"given":"Yvonne C. M.","family":"de Waal","sequence":"additional","affiliation":[{"name":"Center for Dentistry and Oral Hygiene, University Medical Center Groningen and University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2020.101750"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12957"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13564"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12584"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13464"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12562"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13239"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12257"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13757"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13823"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2103020151"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13821"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13914"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40729-021-00388-x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/idj.12490"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2019.vol33.0080"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-023-04918-2"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.14024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:35Z","timestamp":1727136035000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.14024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,4]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/jcpe.14024"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.14024","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,4]]},"assertion":[{"value":"2024-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}