{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:48:58Z","timestamp":1791892138172,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100030982","name":"Straumann Group","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030982","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the clinical and radiographic outcomes of flapless procedure alone or in combination with enamel matrix derivatives (EMD) in the treatment of deep intrabony defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Forty\u2010six patients re\u2010evaluated after non\u2010surgical therapy were randomly assigned to the test (flapless with EMD) or control group (flapless alone). Clinical measurements were recorded pre\u2010surgery and at 6 and 12\u2009months after surgery, and radiographic measurements were taken pre\u2010surgery and after 12\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010six patients completed the study. Improvements were observed in both groups at 12\u2009months for mean clinical attachment level (CAL) gain, with significant differences between test (3.9\u2009\u00b1\u20091.1\u2009mm) and control groups (3.0\u2009\u00b1\u20091.2) (<jats:italic>p<\/jats:italic>\u2009=\u2009.017). Probing pocket depth (PPD) reduction (4.0\u2009\u00b1\u20090.7 vs. 3.3\u2009\u00b1\u20091.4\u2009mm) was also near to statistical significance (<jats:italic>p<\/jats:italic>\u2009=\u2009.051). Also, more sites achieved successful composite outcome measure (final PPD\u2009\u2264\u20094\u2009mm and CAL gain \u22653\u2009mm) for the regenerative treatment in the flapless + EMD group (82.6% vs. 52.2%; <jats:italic>p<\/jats:italic>\u2009=\u2009.028). In terms of radiographic outcomes, EMD yielded a greater defect bone fill than flapless treatment alone (3.0\u2009\u00b1\u20091.0\u2009mm vs. 1.8\u2009\u00b1\u20091.5\u2009mm; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The additional application of EMD during the flapless procedure for intrabony defects slightly improved clinical and radiographic outcomes. <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> identification number: NCT05456555.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.14028","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T05:50:38Z","timestamp":1718085038000},"page":"1112-1121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The flapless approach with and without enamel matrix derivatives for the treatment of intrabony defects: A randomized controlled clinical trial"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0657-0787","authenticated-orcid":false,"given":"Mario","family":"Aimetti","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences C.I.R. 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