{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T11:38:46Z","timestamp":1781350726561,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["539\/2010 A31592"],"award-info":[{"award-number":["539\/2010 A31592"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["308009"],"award-info":[{"award-number":["308009"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["339900"],"award-info":[{"award-number":["339900"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006196","name":"Oulun Yliopisto","doi-asserted-by":"publisher","award":["24000692"],"award-info":[{"award-number":["24000692"]}],"id":[{"id":"10.13039\/501100006196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004012","name":"Jane ja Aatos Erkon S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004012","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Cellular oxygen sensing mechanisms have been linked to periodontal condition, and levels of haemoglobin (Hb) (the main carrier of oxygen) can be used as a surrogate measure for hypoxia. We aimed to examine relations between Hb levels and key periodontal health parameters in a general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The population comprised 1711 (47% male) subjects from the Northern Finland Birth Cohort 1966, for whom an oral health examination was carried out at 46\u2009years of age and whose Hb levels were within the Finnish reference values. Relative risks (RRs) were estimated using Poisson regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The low\u2010Hb tertile (mean Hb 133\u2009g\/L) had healthier anthropometric, metabolic and periodontal health parameters than the high\u2010Hb tertile (mean Hb 151\u2009g\/L). Multivariable regression models adjusted for risk factors showed Hb levels to be positively associated with alveolar bone loss (ABL) and periodontal pocket depth (PPD), although the associations were weaker after adjustment for key metabolic parameters and were strongly influenced by smoking status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hb levels within the normal variation are positively associated with PPD and ABL. The association between Hb levels and periodontal condition appeared to be more complex than had previously been anticipated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.14030","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T07:39:25Z","timestamp":1718350765000},"page":"1168-1177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Higher haemoglobin levels are associated with impaired periodontal status"],"prefix":"10.1111","volume":"51","author":[{"given":"Atte","family":"Tapiola","sequence":"first","affiliation":[{"name":"Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell\u2010Matrix Research University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joona","family":"Tapio","sequence":"additional","affiliation":[{"name":"Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell\u2010Matrix Research University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannu","family":"V\u00e4h\u00e4nikkil\u00e4","sequence":"additional","affiliation":[{"name":"Northern Finland Birth Cohorts, Arctic Biobank, Infrastructure for Population Studies, Faculty of Medicine University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5259-1859","authenticated-orcid":false,"given":"Paula","family":"Tegelberg","sequence":"additional","affiliation":[{"name":"Research Unit of Population Health, Faculty of Medicine University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pekka","family":"Yl\u00f6stalo","sequence":"additional","affiliation":[{"name":"Research Unit of Population Health, Faculty of Medicine University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peppi","family":"Koivunen","sequence":"additional","affiliation":[{"name":"Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell\u2010Matrix Research University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124X.51887"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/JRE.12154"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIADV.ABI4822"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/BMJ.3.5829.731"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(98)90121-4"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12903-022-02455-0"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/JOP.2010.100079"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/438085"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/S12020-015-0587-9"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41368-018-0015-0"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/J.1600-0757.2002.03005.X"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/J.1600-051X.2001.028010930.X"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.MOLCEL.2008.04.009"},{"key":"e_1_2_11_15_1","first-page":"5147","article-title":"New Finnish reference limits for the basic blood count","volume":"58","author":"Kairisto V.","year":"2003","journal-title":"Suomen L\u00e4\u00e4k\u00e4rilehti"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/JOP.2010.100100"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.19-0124"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/IJE\/DYAB109"},{"key":"e_1_2_11_19_1","unstructured":"Northern Finland Birth Cohorts. (2023). Northern finland birth cohorts. University of Oulu.https:\/\/www.oulu.fi\/en\/university\/faculties-and-units\/faculty-medicine\/northern-finland-birth-cohorts-and-arctic-biobank\/research-program-health-and-well-being"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/FPHYS.2016.00416\/BIBTEX"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/S10059-011-1055-X\/METRICS"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3324\/HAEMATOL.13692"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41598-021-99217-9"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/JCPE.13388"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/JCPE.13829"},{"key":"e_1_2_11_26_1","volume-title":"Northern Finland birth cohort 1966","author":"University of Oulu","year":"1966"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/NATURE11677"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/FPHYS.2019.01620\/FULL"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOMATERIALS.2011.09.005"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.14030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T01:05:50Z","timestamp":1723424750000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.14030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,14]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/jcpe.14030"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.14030","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,14]]},"assertion":[{"value":"2023-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}