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Multivariate regression analysis based on cross\u2010sectional data, Mendelian randomization (MR) and multi\u2010omics integration analysis were employed to explore the causal association and potential molecular mechanisms between biological ageing and periodontitis. Additionally, two\u2010step MR mediation analysis explored the risk factors in biological ageing\u2010mediated periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analysed data from 3189 participants in the NHANES data and found that higher biological age was associated with increased risk of periodontitis. MR analyses revealed causal associations between biological age measures and periodontitis risk. Frailty (odds ratio [OR]\u2009=\u20092.08, 95% confidence interval [CI]: 1.04\u20134.18, <jats:italic>p<\/jats:italic>\u2009=\u2009.039) and GrimAge acceleration (OR\u2009=\u20091.16, 95% CI: 1.01\u20131.32, <jats:italic>p<\/jats:italic>\u2009=\u2009.033) were causally associated with periodontitis risk, and these results were validated in a large\u2010scale meta\u2010periodontitis GWAS dataset. Additionally, the risk effects of body mass index, waist circumference and lifetime smoking on periodontitis were partially mediated by frailty and GrimAge acceleration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Evidence from cross\u2010sectional survey and MR analysis suggests that biological ageing increases the risk of periodontitis. Additionally, improving the associated risk factors can help prevent both ageing and periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.14040","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T05:59:28Z","timestamp":1719986368000},"page":"1369-1383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Association between biological ageing and periodontitis: Evidence from a cross\u2010sectional survey and multi\u2010omics Mendelian randomization analysis"],"prefix":"10.1111","volume":"51","author":[{"given":"Zhendong","family":"Huang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology School &amp; Hospital of Stomatology, Wuhan University  Wuhan 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of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology School &amp; Hospital of Stomatology, Wuhan University  Wuhan China"},{"name":"Department of Periodontology School &amp; Hospital of Stomatology, Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology School &amp; Hospital of Stomatology, Wuhan University  Wuhan China"},{"name":"Department of Periodontology School &amp; Hospital of Stomatology, Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4261-9034","authenticated-orcid":false,"given":"Zhengguo","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; 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