{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T20:42:46Z","timestamp":1783629766869,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T00:00:00Z","timestamp":1720915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["7232234"],"award-info":[{"award-number":["7232234"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Periodontitis is one of the most common oral diseases and a major cause of tooth loss in adults. Environmental pollution is closely associated with the prevalence of periodontitis. However, few studies have focused on the association between volatile organic compounds (VOCs) and periodontitis. This cross\u2010sectional study aims to examine whether exposure to VOCs is associated with periodontitis, based on data from the National Health and Nutrition Examination Survey (NHANES, 2011\u20132014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We analysed data on blood VOC levels, periodontitis and related covariates from 2772 participants of the NHANES. The association between the blood VOCs and periodontitis was analysed using weighted logistic regression analysis, the restricted cubic spline (RCS) model and the weighted quantile sum (WQS) regression model. Interaction tests and mediation analysis were also conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After adjusting for covariates, for each natural constant\u2010fold increase in 1,4\u2010dichlorobenzene, the odds of having periodontitis increased by 16% (odds ratio\u2009=\u20091.16; 95% confidence interval: 1.08\u20131.24, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). WQS regression model indicated that 1,4\u2010dichlorobenzene contributed the most to the association between VOC co\u2010exposure and periodontitis. Mediation analysis further revealed that total bilirubin levels mediated the association between 1,4\u2010dichlorobenzene and the prevalence of periodontitis, accounting for 4.32%. In addition, the positive association between <jats:italic>o<\/jats:italic>\u2010xylene and periodontitis was more pronounced in the &lt;65\u2010year\u2010old group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study has provided relatively little evidence to demonstrate a specific link between VOCs and periodontitis. Nonetheless, exposure to VOCs remains a non\u2010negligible public health concern, and further research is required to investigate the association and potential mechanisms of action between VOCs and periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.14041","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T01:09:31Z","timestamp":1721005771000},"page":"1359-1368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association between volatile organic compounds exposure and periodontitis: A representative cross\u2010sectional study"],"prefix":"10.1111","volume":"51","author":[{"given":"Haitao","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Stomatology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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