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Periodontitis patients were re\u2010examined 6\u2009months after non\u2010surgical periodontal therapy (NSPT). Participants were classified according to disease progression: P0 (no sites progressed; P1: 1\u20132 sites progressed; P2: 3 or more sites progressed). Ten salivary and five serum biomarkers were measured using Luminex. Log\u2010transformed levels were compared over time according to baseline diagnosis, progression trajectory and after NSPT. Significant differences were sought using linear mixed models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>P2 presented higher levels (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) of salivary IFN\u03b3, IL\u20106, VEGF, IL\u20101\u03b2, MMP\u20108, IL\u201010 and OPG over time. Serum analytes were not associated with progression. NSPT led to clinical improvement and significant reduction of IFN\u03b3, IL\u20106, IL\u20108, IL\u20101\u03b2, MMP\u20108, IL\u201010, OPG and MMP\u20109 in saliva and of CRP, MMP\u20108, MMP\u20109 and MPO in serum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Periodontitis progression results from a sustained pro\u2010inflammatory milieu that is reflected in salivary biomarkers, but less so in serum, likely because of the limited amount of progression per patient. NSPT can significantly decrease the levels of several salivary analytes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.14048","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T04:08:16Z","timestamp":1722917296000},"page":"1619-1631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Salivary and serum inflammatory biomarkers during periodontitis progression and after treatment"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6945-9811","authenticated-orcid":false,"given":"Flavia R. 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