{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:51:38Z","timestamp":1791348698576,"version":"4.3.1"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019921","name":"Geistlich Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess whether guided bone regeneration (GBR) treatment of peri\u2010implantitis\u2010related bony defects could improve healing compared to open flap debridement (OFD) at 36\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In a multi\u2010centre, randomized clinical trial, 32 individuals received OFD (control group [CG]) and 34 GBR treatment (test group [TG]). Radiographic defect fill (RDF), probing pocket depth (PPD), bleeding on probing (BOP) suppuration (SUP), mucosal recession (MREC) and patient\u2010reported outcomes (PROs) were evaluated at 36\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty individuals attended a supportive peri\u2010implant therapy program and completed the 36\u2010month follow\u2010up. GBR treatment resulted in an RDF of 2.13\u2009\u00b1\u20091.26\u2009mm compared to 1.64\u2009\u00b1\u20091.54\u2009mm following OFD (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.18). No difference was found in PPD, BOP, SUP, REC or PROs between the groups. Successful treatment (no additional bone loss, PPD\u2009\u2264\u20095\u2009mm, no BOP and no SUP) was achieved in 46.2% in TG and 20% in CG (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.053). Treatment results obtained at 12\u2009months were generally maintained up to 36\u2009months. No significant changes were noticed between 12 and 36\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      At 36\u2009months, treatment results obtained at 1 year were sustained following both GBR and OFD in patients attending supportive peri\u2010implant therapy. GBR resulted in more RDF and higher composite treatment success rate than OFD (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      Identifier [NCT02375750]).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.14049","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:20:02Z","timestamp":1721262002000},"page":"1267-1276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The efficacy of reconstructive therapy in the surgical management of peri\u2010implantitis: A 3\u2010year follow\u2010up of a randomized clinical trial"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0992-2362","authenticated-orcid":false,"given":"Stefan","family":"Renvert","sequence":"first","affiliation":[{"name":"Oral Health Sciences Kristianstad University  Kristianstad Sweden"},{"name":"Department of Health Blekinge Institute of Technology  Karlskrona Sweden"},{"name":"Division of Restorative Dentistry &amp; Periodontology Dublin Dental University Hospital, Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Louis","family":"Giovannoli","sequence":"additional","affiliation":[{"name":"Institute of Health University of Corsica  Corte France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Rinke","sequence":"additional","affiliation":[{"name":"Private Practice  Hanau Germany"},{"name":"Department of Prosthodontics University Medical Center  Goettingen 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