{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:22:09Z","timestamp":1790342529540,"version":"4.1.0"},"reference-count":93,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["NIH\/NIDCR DE031431"],"award-info":[{"award-number":["NIH\/NIDCR DE031431"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the influence of diabetes mellitus (DM) in a murine model of peri\u2010implantitis (PI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty\u2010seven 4\u2010week\u2010old C57BL\/6J male mice had their first and second maxillary left molars extracted. Eight weeks later, one machined implant was placed in each mouse. Four weeks after osseointegration, the mice were divided into three groups: (a) control (C), (b) PI and (c) DM\u2009+\u2009PI. DM was induced by streptozotocin (STZ) administration. After DM induction, PI was induced using ligatures for 2\u2009weeks. The hemimaxillae were collected for micro\u2010CT and histological analyses. The primary outcomes consisted of linear (mm) and volumetric (mm<jats:sup>3<\/jats:sup>) bone loss. Secondary outcomes were based on histological analysis and included inflammatory infiltrate, osteoclastic activity, matrix organization, composition and remodelling. Data are presented as means\u2009\u00b1\u2009SEM. Statistical analyses were performed using one\u2010way ANOVA, followed by Tukey's test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Gingival tissue oedema was detected in the PI and DM\u2009+\u2009PI groups. Micro\u2010CT showed significantly increased linear and volumetric bone loss in the DM\u2009+\u2009PI group compared to the C and PI groups. H&amp;E staining showed greater inflammatory response and bone resorption in the PI and DM\u2009+\u2009PI groups than in the C group. The DM\u2009+\u2009PI group had significantly higher osteoclast numbers than the C and PI groups. Picrosirius red stained less for types I and III collagen in the PI and DM\u2009+\u2009PI groups than in the C group. There was a significant increase in monocyte\/macrophage (CD\u201011b) counts and matrix metalloproteinases (MMP\u20102 and MMP\u20108) marker levels and a significant decrease in the matrix metalloproteinases inhibition marker (TIMP\u20102) levels in the DM\u2009+\u2009PI group compared to the C and PI groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DM exacerbates PI\u2010induced soft\u2010tissue inflammation, matrix degradation and bone loss.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.14051","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T05:20:25Z","timestamp":1723526425000},"page":"1511-1523","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Diabetes mellitus exacerbates inflammation in a murine model of ligature\u2010induced peri\u2010implantitis: A histological and microtomographic study"],"prefix":"10.1111","volume":"51","author":[{"given":"Davi N. 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