{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:12:12Z","timestamp":1791353532936,"version":"4.3.1"},"reference-count":64,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association between interleukin\u20108 (IL\u20108) levels in gingival crevicular fluid (GCF) and total oral fluid (TOF) and the responsiveness to steps 1 and 2 of periodontal therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>One\u2010hundred and fifty\u2010nine patients affected by periodontitis received steps 1 and 2 of periodontal therapy. At baseline, TOF and GCF samples were collected and analysed for IL\u20108 (Il\u20108<jats:sub>TOF<\/jats:sub>\/IL\u20108<jats:sub>GCF<\/jats:sub>) using flow cytometry. Therapy outcomes were relative proportions of residual periodontal pockets (PPD%), pocket closure (PC) rates and pocket probing depth (PPD) reductions; these were associated with IL\u20108<jats:sub>TOF<\/jats:sub>\/IL\u20108<jats:sub>GCF<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High IL\u20108<jats:sub>TOF<\/jats:sub> was significantly associated with higher residual PPD% (<jats:italic>p<\/jats:italic>\u2009=\u20090.044) and lower PPD reduction compared to low IL\u20108<jats:sub>TOF<\/jats:sub> (high 0.79\u2009\u00b1\u20091.20\u2009mm vs. low 1.20\u2009\u00b1\u20091.20\u2009mm, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) in non\u2010smokers, while in smokers high IL\u20108<jats:sub>GCF<\/jats:sub> was related to lower PPD reduction (high 0.62\u2009\u00b1\u20091.22\u2009mm vs. low 0.84\u2009\u00b1\u20091.12\u2009mm, <jats:italic>p<\/jats:italic>\u2009=\u20090.009). Furthermore, high baseline IL\u20108<jats:sub>TOF<\/jats:sub> was significantly associated with poorer PC rates compared to medium and low concentrations in both non\u2010smokers (high 41% vs. medium 55% vs. low 58%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and smokers (high 34% vs. medium 44% vs. low 46%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High IL\u20108 concentrations at baseline had a significant impact on residual PPD%, PC rates and PPD reduction. The findings suggest that, especially in non\u2010smokers, baseline IL\u20108 levels collected from the TOF could serve as a component in the estimation of responsiveness to steps 1 and 2 of periodontal therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.14055","type":"journal-article","created":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T06:43:40Z","timestamp":1723877020000},"page":"1433-1442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Role of Interleukin\u20108 in the Estimation of Responsiveness to Steps 1 and 2 of Periodontal Therapy"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0681-1528","authenticated-orcid":false,"given":"Caspar\u00a0Victor","family":"Bumm","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Periodontology LMU University Hospital, LMU Munich  Munich Germany"},{"name":"Private Practice  Munich 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