{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:13:12Z","timestamp":1791663192617,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002706","name":"AFA F\u00f6rs\u00e4kring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002706","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>The study \u2018Periodontitis and Its Relation to Coronary Artery Disease\u2019 (PAROKRANK) reported an association between periodontitis (PD) and the first myocardial infarction (MI). This follow\u2010up study aims to test the hypothesis that those with PD\u2014compared to periodontally healthy individuals\u2014are at increased risk for cardiovascular (CV) events and death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 1587 participants (age &lt;75\u2009years; females 19%) had a dental examination including panoramic radiographs between 2010 and 2014. PD was categorized as healthy (\u226580% alveolar bone height), mild\/moderate (79%\u201366%) or severe (&lt;66%). A composite CV event (first of all\u2010cause death, non\u2010fatal MI or stroke and hospitalization following to heart failure) was investigated during a mean follow\u2010up period of 9.9\u2009years (range 0.2\u201312.5\u2009years). Participants were divided into two groups: those with and without PD. The primary event rate, stratified by periodontal status at baseline, was calculated using the Kaplan\u2013Meier method and Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The number of events was 187 in the 985 periodontally healthy participants (19%) and 174 in the 602 participants with PD (29%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Those with PD had a higher likelihood for a future event (hazard ratio [HR] =\u20091.26; 95% CI: 1.01\u20131.57;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038), following adjustment for age, smoking and diabetes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The PAROKRANK follow\u2010up revealed that CV events were more common among participants with PD, which supports the assumption that there might be a direct relation between PD and CV disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.14064","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T23:53:37Z","timestamp":1726098817000},"page":"16-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Does Periodontitis Increase the Risk for Future Cardiovascular Events? Long\u2010Term Follow\u2010Up of the\n                    <scp>PAROKRANK<\/scp>\n                    Study"],"prefix":"10.1111","volume":"52","author":[{"given":"Anna","family":"Norhammar","sequence":"first","affiliation":[{"name":"Department of Medicine K2 Karolinska Institutet and Karolinska University Hospital Solna  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"N\u00e4sman","sequence":"additional","affiliation":[{"name":"Department of Medicine K2 Karolinska Institutet and Karolinska University Hospital Solna  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e5re","family":"Buhlin","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"de Faire","sequence":"additional","affiliation":[{"name":"Department of Medicine K2 Karolinska Institutet and Karolinska University Hospital Solna  Stockholm Sweden"},{"name":"Division of Cardiovascular Epidemiology IMM Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Ferrannini","sequence":"additional","affiliation":[{"name":"Department of Medicine K2 Karolinska Institutet and Karolinska University Hospital Solna  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbro","family":"Kjellstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Medicine K2 Karolinska Institutet and Karolinska University Hospital Solna  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kvist","sequence":"additional","affiliation":[{"name":"Department of Endodontology, Institute of Odontology, The Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Levring","family":"J\u00e4ghagen","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Radiology, Department of Odontology, Faculty of Medicine Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertil","family":"Lindahl","sequence":"additional","affiliation":[{"name":"Department Medical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5ke","family":"Nygren","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Danderyd Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"N\u00e4slund","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Svenungsson","sequence":"additional","affiliation":[{"name":"Department of Medicine K2 Karolinska Institutet and Karolinska University Hospital Solna  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Klinge","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Faculty of Odontology, Department of Periodontology Malm\u00f6 University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Ryd\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Medicine K2 Karolinska Institutet and Karolinska University Hospital Solna  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the PAROKRANK Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"i1","article-title":"1999 International Workshop for a Classification of Periodontal Diseases and Conditions. 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