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Motor function assessments were conducted before and after periodontitis induction in controls and 6\u2010OHDA\u2010injury\u2010induced rats. Tissue samples from the striatum, jaw and blood were collected for molecular analyses, encompassing immunohistochemistry of tyrosine hydroxylase, microglia and astrocyte, as well as micro\u2010computed tomography, to assess alveolar bone loss and for the analysis of striatal oxidative stress and plasma inflammatory markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results indicated motor impairment in 6\u2010OHDA\u2010injury\u2010induced rats exacerbated by periodontitis, worsening dopaminergic striatal degeneration. Periodontitis alone or in combination with 6\u2010OHDA\u2010induced lesion was able to increase striatal microglia, while astrocytes were increased by the combination only. Periodontitis increased striatal reactive oxygen species levels and plasma tumour necrosis factor\u2010alpha levels in rats with 6\u2010OHDA\u2010induced lesions and decreased the anti\u2010inflammatory interleukin\u201010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provides original insights into the association between periodontitis and a neurodegenerative condition. The increased inflammatory pathway associated with both 6\u2010OHDA\u2010induced dopaminergic neuron lesion and periodontal inflammatory processes corroborates that the periodontitis\u2010induced systemic inflammation may aggravate neuroinflammation in Parkinson's\u2010like disease, potentially hastening disease progression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.14065","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T01:34:54Z","timestamp":1725327294000},"page":"159-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Experimental Periodontitis Worsens Dopaminergic Neuronal Degeneration"],"prefix":"10.1111","volume":"52","author":[{"given":"Gabrielle","family":"Jacob","sequence":"first","affiliation":[{"name":"Department of Basic and Oral Biology, School of Dentistry of Ribeirao Preto University of Sao Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo 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