{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:05:35Z","timestamp":1792109135185,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007195","name":"Universit\u00e0 degli Studi di Napoli Federico II","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007195","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the clinical outcomes of moderate intrabony defects treated with minimally invasive non\u2010surgical technique (MINST) with or without adjunctive delivery of cross\u2010linked hyaluronic acid (xHyA) gel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Forty\u2010two patients with 42 interdental intrabony defects were randomly assigned to test (MINST + xHyA) or control procedures (MINST alone). Probing depth (PD), clinical attachment level (CAL), gingival recession (GR) and bleeding on probing (BOP) at the treated sites were assessed at baseline and at 3\u2009and 6\u2009months. Full\u2010mouth plaque score (FMPS) and full\u2010mouth bleeding score (FMBS) were recorded at baseline and after 6\u2009months. Radiographic evaluation was performed at baseline and after 6\u2009months, assessing the defect fill (DF) and radiographic defect angle (RDA). The primary outcome variable was PD change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010eight patients completed the trial without any adverse events. At 6\u2009months, a statistically significant improvement (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) was measured in all clinical parameters except GR (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). However, no statistically significant differences were found between the experimental and control procedures (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Statistically significant differences between the test and control sites were observed at 3\u2009months for PD and CAL changes (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The DF change was statistically significant when comparing experimental and control procedures at 6\u2009months (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Both procedures failed to show statistically significant differences in terms of RDA changes at 6\u2009months (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within their limitations, the present results indicate that (a) treatment of intrabony defects with MINST, with or without application of xHyA gel, resulted in statistically significant improvements in the investigated clinical parameters at 3 and 6\u2009months after therapy, and (b) although the adjunctive use of xHyA gel to MINST improved the clinical outcomes compared with MINST alone up to 3\u2009months, statistically significant differences were not observed at 6\u2009months. The study protocol was registered in <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrial.gov\">ClinicalTrial.gov<\/jats:ext-link> (NCT05188898).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.14078","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T06:39:39Z","timestamp":1728974379000},"page":"310-322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Non\u2010Surgical Treatment of Moderate Periodontal Intrabony Defects With Adjunctive Cross\u2010Linked Hyaluronic Acid: A\u00a0Single\u2010Blinded Randomized Controlled Clinical Trial"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1968-0021","authenticated-orcid":false,"given":"Vincenzo","family":"Iorio\u2010Siciliano","sequence":"first","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Naples Federico II 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