{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:48:52Z","timestamp":1788929332730,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the effect of periodontitis on the long\u2010term changes of the cardio\u2010ankle vascular index (CAVI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A 10\u2010year retrospective cohort study of 3842 Thai participants (range 25\u201376\u2009years) with normal CAVI at the study initiation was undertaken. Full\u2010mouth periodontal examination was performed by calibrated periodontists, and the extent and severity of periodontitis were determined at 5\u2010year intervals. Serial CAVI measurements were used to examine the incidence of high CAVI (\u2265\u20099.0) and changes in CAVI over time (\u0394CAVI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants with a higher extent or severity of periodontitis were found to have a significantly higher mean \u0394CAVI. The incidence of high CAVI was also observed to be higher in those with periodontitis compared to those without it. The adjusted risk ratios for developing high CAVI were 1.309 and 1.513 for localized and generalized periodontitis, respectively. Participants with severe periodontitis had a 37% higher likelihood of developing CAVI \u2265\u20099.0 compared to individuals with no\/mild periodontitis. This risk was consistent with a significant change in \u0394CAVI of 0.054\u20130.140.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Periodontitis, both in terms of extent and severity, was found to have a significant dose\u2010dependent effect on the risk of developing high CAVI over a 10\u2010year period, suggesting a causal relationship between these two parameters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.14086","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:59:02Z","timestamp":1730941142000},"page":"363-374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Periodontitis Is Associated With Arterial Stiffness as Measured by Serial Cardio\u2010Ankle Vascular Index (<scp>CAVI<\/scp>): A\u00a010\u2010Year Cohort Study"],"prefix":"10.1111","volume":"52","author":[{"given":"Bantita","family":"Kanpittaya","sequence":"first","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attawood","family":"Lertpimonchai","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"},{"name":"Center of Excellence in Periodontal Disease\u00a0and\u00a0Dental Implant, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanutm","family":"Mongkornkarn","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"},{"name":"Center of Excellence in Periodontal Disease\u00a0and\u00a0Dental Implant, Faculty of Dentistry Chulalongkorn University  Bangkok 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