{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:43:48Z","timestamp":1784825028830,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T00:00:00Z","timestamp":1731196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To analyse whether some selected inflammatory biomarkers collected from venous blood and gingival crevicular fluid (GCF) were associated with the outcome of non\u2010surgical periodontal therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Two\u2010hundred and nine patients affected by periodontitis were enrolled in the study, who had undergone steps I and II therapy as well as a non\u2010surgical re\u2010instrumentation (NSRI) of periodontal pockets after 6\u2009months. Serum (SE), plasma (PL) and GCF samples were quantitatively analysed for the following inflammatory biomarkers: active matrix metalloproteinase\u20108 (aMMP\u20108), prostaglandin E2 (PGE2) and surfactant protein D (SP\u2010D). Therapy outcomes were evaluated using a \u2018treat\u2010to\u2010target\u2019 endpoint (T2T) at the patient level, defined as \u2264\u20094 sites with pocket depth \u2265\u20095\u2009mm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients presented with 23\u2009\u00b1\u20096 teeth (mean\u2009\u00b1\u2009SD) at baseline. After steps I and II therapy, 41.6% of the patients reached T2T and after NSRI 47.4%. Univariate analysis identified a potential association between high levels of PL\u2010SP\u2010D and more favourable treatment outcomes. Multivariate binary logistic regression adjusted for sex, mean baseline probing depth, diabetes and current smoking status confirmed an independent relationship between baseline PL\u2010SP\u2010D and the T2T after steps I and II therapy (aOR 0.432, <jats:italic>p<\/jats:italic>\u2009=\u20090.011), implying that a higher level PL\u2010SP\u2010D at baseline is associated with a &gt;\u200950% reduced risk of failing T2T. However, no such association was found for PL\u2010SP\u2010D and NSRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher baseline PL\u2010SP\u2010D levels might be associated with more favourable treatment outcomes after steps I and II therapy. This may be due to its role in the regulation of neutrophil function. However, further investigation is required to confirm this hypothesis. If proven, PL\u2010SP\u2010D could play a role as a biomarker for identifying individuals who respond differentially to primary therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.14089","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T03:04:53Z","timestamp":1731294293000},"page":"188-198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Study Into Systemic and Oral Levels of Proinflammatory Biomarkers Associated With Endpoints After Active Non\u2010Surgical Periodontal Therapy"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8498-0736","authenticated-orcid":false,"given":"Nils","family":"Werner","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Periodontology LMU University Hospital, LMU Munich  Munich 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