{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T08:43:34Z","timestamp":1788857014216,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100019921","name":"Geistlich Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to investigate the non\u2010inferiority of alveolar ridge preservation (ARP) with membrane stabilization compared with non\u2010stabilization, focusing on changes of soft\u2010tissue contour in periodontally compromised extraction sockets. Secondary outcomes included changes in hard\u2010tissue contour, patient\u2010reported outcomes and new bone formation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty\u2010four patients with periodontally compromised teeth were randomly assigned to ARP with (test group) or without (control group) membrane stabilization. To assess profilometric and hard\u2010tissue dimensional changes, dental impressions and cone beam computed tomography scans were performed at baseline (T0), immediately after ARP (T1) and 4\u2009months post surgery (T2). Soft\u2010tissue healing in open healing sites was evaluated at T2, and wound closure was assessed 10\u2009days post surgery. Patient\u2010reported outcomes were documented, and core biopsies were obtained for histomorphometric analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The absolute profilometric horizontal width change at 3\u2009mm below the crest in the test group was not inferior to that in the control group. For the relative values, horizontal width reduction (3 and 5\u2009mm below the crest) and volumetric shrinkage (3\u20135\u2009mm below the crest) were lower in the test group. No significant differences were observed in bone dimensional changes, wound healing, pain and swelling or histomorphometric outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ARP with membrane stabilization in periodontally compromised extraction sockets is non\u2010inferior in terms of soft\u2010tissue contour changes to those without membrane fixation.<\/jats:p><jats:p>\n<jats:bold>Trial Registration:<\/jats:bold> Clinical Research Information Service (CRIS), KCT0005280. Registered 4 August 2020, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/cris.nih.go.kr\/cris\/search\/detailSearch.do?seq=19165&amp;search_page=L\">https:\/\/cris.nih.go.kr\/cris\/search\/detailSearch.do?seq=19165&amp;search_page=L<\/jats:ext-link>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.14092","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T09:58:47Z","timestamp":1733824727000},"page":"471-483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Impact of Membrane Stabilization for Alveolar Ridge Preservation in Periodontally Compromised Extraction Sockets: A Non\u2010Inferiority Randomized Controlled Trial"],"prefix":"10.1111","volume":"52","author":[{"given":"Seung\u2010Ju","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Periodontology and Dental Research Institute, School of Dentistry Seoul National 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