{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:29:32Z","timestamp":1788960572094,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the adjunctive effect of periodontal therapy on psoriasis\u2010related outcomes in a combined experimental model of ligature\u2010induced periodontitis and Imiquimod (IMQ)\u2010induced psoriasis. Also, this experiment aimed to study the impact of TNF\u2010\u03b1 inhibitors on the periodontium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010six C57\/BL6J mice were randomly allocated to seven experimental groups: (a) control group (P\u2013Pso\u2013) with no treatment; (b) periodontitis (P+Pso\u2013) with periodontal therapy; (c) periodontitis (P+Pso\u2013) with TNF\u2010\u03b1 inhibitor; (d) psoriasis (P\u2013Pso+) with TNF\u2010\u03b1 inhibitor; (e) periodontitis and psoriasis (P+Pso+) with periodontal therapy; (f) P+Pso+\u2009with TNF\u2010\u03b1 inhibitor; and (g) P+Pso+\u2009with both periodontal therapy and TNF\u2010\u03b1 inhibitor. Samples (maxilla, dorsal skin and blood) were harvested immediately after death. Measures of periodontitis distance between the cemento\u2010enamel junction and alveolar bone crest (CEJ\u2013ABC) and number of osteoclasts and psoriasis (epidermal thickness and infiltrate cells (per 0.03mm\n                      <jats:sup>2<\/jats:sup>\n                      )) severity, as well as systemic inflammation (IL\u20106, IL\u201017A and TNF\u2010\u03b1) were collected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the P+Pso+\u2009group, a significant adjunctive effect of periodontal therapy to TNF\u2010\u03b1 inhibitors was found in the reduction of epidermal thickening and inflammatory infiltrate of the dorsal skin (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Similarly, treatment with TNF\u2010\u03b1 inhibitor resulted in a significant adjunctive effect to periodontal therapy in the reduction of alveolar bone loss (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). These changes were accompanied by a significant decrease in the circulating levels of IL\u20106 and IL\u201017A when both periodontal therapy and TNF\u2010\u03b1 inhibitor were administered.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The combination of periodontal therapy and TNF\u2010\u03b1 inhibitor showed a positive synergetic effect in the treatment of comorbid experimental ligature\u2010induced periodontitis and IMQ\u2010induced psoriasis via the reduction of systemic inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.14102","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T07:20:57Z","timestamp":1745565657000},"page":"907-919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Synergetic Effect of Periodontal Therapy and\n                    <scp>TNF<\/scp>\n                    \u2010\u03b1 Inhibitor for the Treatment of Comorbid Periodontitis and Psoriasis"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1088-2046","authenticated-orcid":false,"given":"Crystal","family":"Marruganti","sequence":"first","affiliation":[{"name":"Unit of Periodontology, Endodontology and Restorative Dentistry, Department of Medical Biotechnologies University of Siena  Siena Italy"},{"name":"Periodontology Unit, UCL Eastman Dental Institute and Hospital University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Gaeta","sequence":"additional","affiliation":[{"name":"Unit of Periodontology, Endodontology and Restorative Dentistry, Department of Medical Biotechnologies University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Falciani","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Cinotti","sequence":"additional","affiliation":[{"name":"Unit of Dermatology, Department of Medical, Surgical and Neurological Science University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Rubegni","sequence":"additional","affiliation":[{"name":"Unit of Dermatology, Department of Medical, Surgical and Neurological Science University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Alovisi","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, C.I.R. 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