{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T17:36:19Z","timestamp":1778175379653,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine bone regeneration following sinus floor elevation (SFE) at sites with or without prior sinus membrane perforation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The sinus membranes in the maxillary sinuses of 12 rabbits were intentionally perforated (\u2265\u20095\u2009mm) on one side, followed by application of a collagen matrix. SFE was performed on both sinuses after 8\u2009weeks of healing, presenting two groups: SFE with a previous large sinus membrane perforation (group SFE_Perf), and in an intact sinus (group SFE). The animals were euthanized at 2 and 4\u2009weeks after SFE. Micro\u2010computed tomographic and histomorphometric analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The amount of newly formed bone within the augmented area did not differ significantly between the two groups at 2\u2009weeks and 4\u2009weeks (4.7\u2009\u00b1\u20091.0\u2009mm<jats:sup>2<\/jats:sup> vs. 5.3\u2009\u00b1\u20091.4\u2009mm<jats:sup>2<\/jats:sup> and 9.2\u2009\u00b1\u20091.7\u2009mm<jats:sup>2<\/jats:sup> vs. 10.8\u2009\u00b1\u20092.2\u2009mm<jats:sup>2<\/jats:sup>, respectively, mean\u2009\u00b1\u2009SD; <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). However, the amount of newly formed bone near the middle of the sinus membranes was significantly greater in group SFE than in group SFE_Perf (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). There was no significant difference in the augmented volume. Fewer subepithelial glands and denser collagen fibres within the sinus membranes were observed in group SFE_Perf than in group SFE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A large perforation of the sinus membrane followed by an 8\u2010week healing period did not jeopardize new bone formation following SFE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.14108","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T11:53:42Z","timestamp":1735214022000},"page":"421-433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bone Regeneration After Sinus Floor Elevation in an Intact Sinus or a Sinus With Prior Large Membrane Perforation: A Preclinical Study Using a Rabbit Sinus Model"],"prefix":"10.1111","volume":"52","author":[{"given":"Sunmin","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Dentistry, Graduate School Kyung Hee University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2678-1525","authenticated-orcid":false,"given":"Jong\u2010Hyuk","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Periodontology Kyung Hee University College of Dentistry, Periodontal\u2010Implant Clinical Research Institute, Kyung Hee University Medical Center  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1764-7447","authenticated-orcid":false,"given":"Daniel S.","family":"Thoma","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2055-1320","authenticated-orcid":false,"given":"Ronald E.","family":"Jung","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6371-4172","authenticated-orcid":false,"given":"Ui\u2010Won","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Research Institute for Periodontal Regeneration Yonsei University College of Dentistry  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6980-7556","authenticated-orcid":false,"given":"Seung\u2010Yun","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Periodontology Kyung Hee University College of Dentistry, Periodontal\u2010Implant Clinical Research Institute, Kyung Hee University Medical Center  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7695-1708","authenticated-orcid":false,"given":"Hyun\u2010Chang","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Periodontology Kyung Hee University College of Dentistry, Periodontal\u2010Implant Clinical Research Institute, Kyung Hee University Medical Center  Seoul Republic of Korea"},{"name":"Clinic of Reconstructive Dentistry University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8091491"},{"key":"e_1_2_10_3_1","first-page":"160","article-title":"Influence of Anatomy on Schneiderian Membrane Perforations During Sinus Elevation Surgery: Three\u2010Dimensional Analysis","volume":"13","author":"Cho S. 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