{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T08:10:04Z","timestamp":1751271004250,"version":"3.41.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004488","name":"Hrvatska Zaklada za Znanost","doi-asserted-by":"publisher","award":["IP\u20102020\u201002\u20104027"],"award-info":[{"award-number":["IP\u20102020\u201002\u20104027"]}],"id":[{"id":"10.13039\/501100004488","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To quantify changes in soft\u2010tissue volume induced by non\u2010surgical periodontal therapy (NSPT) in patients with periodontitis and correlate them with clinical parameters and smoking. A new digital approach is investigated because standard periodontal clinical assessment methods are unable to accurately capture volumetric changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Thirty\u2010nine subjects with periodontitis aged 27\u201370\u2009years (median 48; 51% females; 49% smokers) were included. All subjects underwent clinical examination and intraoral scanning at baseline and 8\u2009weeks after NSPT. Digital models were superimposed, and changes in volume were analysed and correlated with clinical parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NSPT reduced soft\u2010tissue volume in both smokers and non\u2010smokers (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Non\u2010smokers had a higher median change in volume than smokers (267.4 vs. 210.5\u2009mm<jats:sup>3<\/jats:sup>), without statistically significant differences. Periodontal clinical parameters linearly correlated with soft\u2010tissue volume changes. In multiple linear regression, a higher initial proportion of pockets \u2265\u20095\u2009mm was the only predictor of volume change when the effects of change in plaque score, smoking status, age and sex were controlled for (<jats:italic>p<\/jats:italic>\u2009=\u20090.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NSPT resulted in comparable reductions in soft\u2010tissue volume for both smokers and non\u2010smokers, which was confirmed by a new digital approach.<\/jats:p><jats:p>\n<jats:bold>Trial Registration:<\/jats:bold> <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>: NCT05719519, 25.01.2023<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.14118","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:55:02Z","timestamp":1744764902000},"page":"888-897","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A New Method for Volumetric Analysis of Soft\u2010Tissue Changes Using Three\u2010Dimensional Imaging in Patients With Periodontitis"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9478-2060","authenticated-orcid":false,"given":"Aleksandar","family":"Pupovac","sequence":"first","affiliation":[{"name":"Department of Periodontology, Faculty of Dental Medicine University of Rijeka  Rijeka Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8558-8450","authenticated-orcid":false,"given":"Davor","family":"Kui\u0161","sequence":"additional","affiliation":[{"name":"Department of 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