{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:56:36Z","timestamp":1788900996178,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["07182796"],"award-info":[{"award-number":["07182796"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301157"],"award-info":[{"award-number":["82301157"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the diagnostic accuracy of an active matrix metalloproteinase\u20108 (aMMP\u20108) point\u2010of\u2010care oral rinse test (POC\u2010ORT) for predicting periodontitis in treatment\u2010na\u00efve subjects in two independent studies and update a recent meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The aMMP\u20108 POC\u2010ORT index test was performed in a representative population in Hong Kong, China, and a consecutive convenience sample in Shanghai, China. The reference standard was the 2017 World Workshop classification of periodontal diseases. Sensitivity, specificity, and the area under the receiver operating characteristic (AUROC) curve were assessed. The original data were used to update a recent Bayesian meta\u2010analysis following the current Cochrane guideline for diagnostic trials. The GRADE framework was used to interpret the strength and certainty of the evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Three\u2010hundred and eighty\u2010four and 390 subjects were enrolled in the Hong Kong and Shanghai studies, respectively; 74.5% and 67.2% had periodontitis. An aMMP\u20108\u2010positive test predicted periodontitis with an AUROC of 0.661 and 0.669 in the two studies. The updated systematic review and meta\u2010analysis included eight studies and 2048 subjects. After considering the risk of bias, indirectness, inconsistency, imprecision and publication bias, it showed moderate certainty of a sensitivity of 0.59 (95% CrI: 0.42\u20130.75), a specificity of 0.82 (95% CrI: 0.68\u20130.93) and a hierarchical summary AUROC of 0.77 (95% CrI: 0.74\u20130.81).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is moderate certainty that the aMMP\u20108 POC\u2010ORT test predicts periodontitis with low to moderate sensitivity, moderate to high specificity, and moderate accuracy. Its high false\u2010negative rate does not allow the replacement of clinical examinations\u00a0when available. The moderate to high positive predictive value shows the potential utility of a positive test for self\u2010detection or co\u2010management of periodontitis in a medical setting and its incorporation in multi\u2010test diagnostics. Further investigations are highly warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.14119","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:21:33Z","timestamp":1736814093000},"page":"510-529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Diagnostic Accuracy of a Point\u2010Of\u2010Care\n                    <scp>aMMP<\/scp>\n                    \u20108 Test for Discriminating Periodontal Health Status in Adults: Validation Trials and Updated Meta\u2010Analysis"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0133-7516","authenticated-orcid":false,"given":"Yuan","family":"Li","sequence":"first","affiliation":[{"name":"Perio\u2010Implant Innovation Center, Institute for Integrated Oral, Craniofacial and Sensory Research and Department of Oral and Maxillofacial Implantology and National Clinical Research Center of Stomatology, Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie Choi Ka","family":"Kung","sequence":"additional","affiliation":[{"name":"Division of Periodontology and Implant Dentistry, Faculty of Dentistry The University of Hong Kong  Pok Fu Lam Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Shi","sequence":"additional","affiliation":[{"name":"Perio\u2010Implant Innovation Center, Institute for Integrated Oral, Craniofacial and Sensory Research and Department of Oral and Maxillofacial Implantology and National Clinical Research Center of Stomatology, Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1310-1452","authenticated-orcid":false,"given":"Xinyu","family":"Wu","sequence":"additional","affiliation":[{"name":"Perio\u2010Implant Innovation Center, Institute for Integrated Oral, Craniofacial and Sensory Research and Department of Oral and Maxillofacial Implantology and National Clinical Research Center of Stomatology, Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve Lut Ting","family":"Lam","sequence":"additional","affiliation":[{"name":"Division of Periodontology and Implant Dentistry, Faculty of Dentistry The University of Hong Kong  Pok Fu Lam Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Deng","sequence":"additional","affiliation":[{"name":"Division of Periodontology and Implant Dentistry, Faculty of Dentistry The University of Hong Kong  Pok Fu Lam Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Perio\u2010Implant Innovation Center, Institute for Integrated Oral, Craniofacial and Sensory Research and Department of Oral and Maxillofacial Implantology and National Clinical Research Center of Stomatology, Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6922-2918","authenticated-orcid":false,"given":"Hongchang","family":"Lai","sequence":"additional","affiliation":[{"name":"Perio\u2010Implant Innovation Center, Institute for Integrated Oral, Craniofacial and Sensory Research and Department of Oral and Maxillofacial Implantology and National Clinical Research Center of Stomatology, Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  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