{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T13:22:11Z","timestamp":1792761731404,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T00:00:00Z","timestamp":1736640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301084"],"award-info":[{"award-number":["82301084"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515110379"],"award-info":[{"award-number":["2022A1515110379"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022QH278"],"award-info":[{"award-number":["ZR2022QH278"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Masticatory dysfunction due to tooth loss is a potentially modifiable risk for mortality, but the pathway behind that remains to be investigated. This prospective study aimed to examine the role of diet and ageing in the associations between chewing capacity and long\u2010term mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data were obtained from participants (aged \u2265\u200920) in the National Health Nutritional and Health Survey (NHANES 1999\u20132010,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922,900). The mortality follow\u2010up ended on 31 December 2019. Chewing capacity was determined by the number of functional tooth units (FTUs). Diet information in NHANES was collected using a 24\u2010h\u2010recall questionnaire, and diet quality was measured by three index\u2010based dietary patterns, namely the nutrition index (NI), energy\u2010adjusted dietary inflammatory index (E\u2010DII) and healthy eating index\u20102015 (HEI\u20102015). The biological ageing process was reflected using phenotypic age acceleration (PhenoAgeAccel) and frailty index. Mediation analyses were conducted to assess the role of diet quality in the association between FTUs and ageing, as well as the role of ageing in the association between impaired chewing capacity (ICC) and mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participants with more FTUs were found to have a slower biological ageing process. Diet quality scores were estimated to mediate 9.0%\u201323.0% of the association between chewing capacity and biological ageing. Multivariable Cox proportional hazards regression models found a positive association between ICC and all\u2010cause mortality (hazard ratio\u2009=\u20091.282 [95% confidence interval: 1.189\u20131.382]). Also, ICC was significantly associated with a 28.9% higher risk of mortality due to cardiovascular disease (CVD) and a 32.7% higher risk of mortality due to cancer. Mediation analyses indicated that PhenoAgeAccel mediated the effect of ICC on all\u2010cause, CVD and cancer mortality with proportions of 18.1%, 17.3% and 12.5%, respectively. Similar mediating proportions were observed in the frailty index (range: 11.6%\u201323.5%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ICC was associated with poorer diet quality and accelerated ageing, resulting in higher mortality risk. Therefore, it is plausible that dietary interventions and oral rehabilitation would promote healthy longevity, although further investigations are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.14122","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:49:03Z","timestamp":1736729343000},"page":"695-706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Association Between Chewing Capacity and Mortality Risk: The Role of Diet and Ageing"],"prefix":"10.1111","volume":"52","author":[{"given":"Mi","family":"Du","sequence":"first","affiliation":[{"name":"School and Hospital of Stomatology, Cheeloo College of Medicine Shandong University &amp; Shandong Provincial Clinical Research Center for Oral Diseases  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Deng","sequence":"additional","affiliation":[{"name":"Division of Periodontology and Implant Dentistry, Faculty of Dentistry The University of Hong Kong  Pok Fu Lam Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety &amp; Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenkai","family":"Wu","sequence":"additional","affiliation":[{"name":"Global Health Research Center Duke Kunshan University  Kunshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixian","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Precision Medicine, The First Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Department of Gastroenterology and Hepatology, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxu","family":"Guo","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology, Cheeloo College of Medicine Shandong University &amp; Shandong Provincial Clinical Research Center for Oral Diseases  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixin","family":"Luo","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology, Cheeloo College of Medicine Shandong University &amp; Shandong Provincial Clinical Research Center for Oral Diseases  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2743-0137","authenticated-orcid":false,"given":"Maurizio","family":"Tonetti","sequence":"additional","affiliation":[{"name":"Shanghai PerioImplant Innovation Center, Department of Oral and Maxillofacial Implantology, National Clinical Research Center of Stomatology, Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geerten\u2010Has E.","family":"Tjakkes","sequence":"additional","affiliation":[{"name":"Center for Dentistry and Oral Hygiene, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Visser","sequence":"additional","affiliation":[{"name":"Center for Dentistry and Oral Hygiene, University Medical Center Groningen University of Groningen  Groningen The Netherlands"},{"name":"Department for Gerodontology, College of Dental Sciences Radboud University Nijmegen Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3821-5480","authenticated-orcid":false,"given":"Shaohua","family":"Ge","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology, Cheeloo College of Medicine Shandong University &amp; 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