{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T14:37:40Z","timestamp":1772635060577,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003758","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o","doi-asserted-by":"publisher","award":["01732\/21"],"award-info":[{"award-number":["01732\/21"]}],"id":[{"id":"10.13039\/501100003758","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003758","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o","doi-asserted-by":"publisher","award":["88887.568435\/2020\u201000"],"award-info":[{"award-number":["88887.568435\/2020\u201000"]}],"id":[{"id":"10.13039\/501100003758","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["financecode001"],"award-info":[{"award-number":["financecode001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006506","name":"Minist\u00e9rio da Sa\u00fade","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the association between molar incisor hypomineralization (MIH) and periodontitis in adolescents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A population\u2010based study was undertaken of Brazilian adolescents aged 18 and 19\u2009years (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092515). MIH was assessed according to Ghanim's criteria. The outcomes were Periodontitis Indicators, a continuous latent variable estimated on the basis of the common variance shared by the indicators bleeding on probing (BoP), probing pocket depth (PPD\u2009\u2265\u20094\u2009mm) and clinical attachment level (CAL\u2009\u2265\u20093\u2009mm), as well as periodontitis cases defined according to CDC\u2010AAP. Structural equation modelling was used, and the models were adjusted for lower socioeconomic status, sex, smoking, triglycerides\/high\u2010density lipoprotein (TG\/HDL) (mg\/dL) and visible plaque index. Two other approaches were used for sensitivity analysis: (i) logistic regression, considering the effect of MIH on periodontitis (CDC\/AAP) at the individual level, and (ii) multilevel regression to evaluate the association of MIH with CAL and PPD, considering the tooth as the unit of analysis, adjusted for other tooth\u2010level and individual\u2010level variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of MIH was 16.86% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009423). Individuals with MIH had higher values of the Periodontitis Indicators through a direct pathway (standardized coefficient [SC]\u2009=\u20090.193,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and indirectly mediated by biofilm (SC\u2009=\u20090.263,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). MIH was also associated with periodontitis according to CDC\u2010AAP (SC\u2009=\u20090.071,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and indirectly mediated by biofilm (SC\u2009=\u20090.344,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Consistently, lower socioeconomic status, sex, TG\/HDL and biofilm were associated with both periodontal outcomes. Tooth\u2010level sensitivity regression analysis confirmed the association observed in individual\u2010level analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that adolescents with MIH are susceptible to periodontitis, and it is therefore important to monitor their periodontal health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.14123","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T22:14:25Z","timestamp":1737584065000},"page":"530-538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Molar Incisor Hypomineralization and Periodontitis in Adolescents: A Population\u2010Based Study"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9144-6793","authenticated-orcid":false,"given":"Marcela Mayana Pereira","family":"Franco","sequence":"first","affiliation":[{"name":"Postgraduate Program in Dentistry Federal University of Maranh\u00e3o  S\u00e3o Luis Maranh\u00e3o Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0041-7618","authenticated-orcid":false,"given":"Cecilia Claudia Costa","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry Federal University of Maranh\u00e3o  S\u00e3o Luis Maranh\u00e3o Brazil"},{"name":"Department of Dentistry II Federal University of Maranh\u00e3o (UFMA)  S\u00e3o Luis Maranh\u00e3o Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena L\u00facia Costa","family":"Ladeira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry Federal University of Maranh\u00e3o  S\u00e3o Luis Maranh\u00e3o Brazil"},{"name":"Postgraduate Program in Dentistry CEUMA University  Sao Luis Maranh\u00e3o Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2437-4552","authenticated-orcid":false,"given":"Mario Augusto","family":"Brondani","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences, Faculty of Dentistry University of British Columbia (UBC)  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4156-4067","authenticated-orcid":false,"given":"Erika B\u00e1rbara Abreu Fonseca","family":"Thomaz","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry Federal University of Maranh\u00e3o  S\u00e3o Luis Maranh\u00e3o Brazil"},{"name":"Department of Public Health Federal University of Maranh\u00e3o  S\u00e3o Luis Maranh\u00e3o 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