{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:49:00Z","timestamp":1778802540842,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T00:00:00Z","timestamp":1736640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T00:00:00Z","timestamp":1736640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071128"],"award-info":[{"award-number":["82071128"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270988"],"award-info":[{"award-number":["82270988"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016808","name":"Natural Science Foundation of Xiamen Municipality","doi-asserted-by":"publisher","award":["3502Z20227291"],"award-info":[{"award-number":["3502Z20227291"]}],"id":[{"id":"10.13039\/100016808","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Circular RNA forkhead box O3 (circFOXO3) is crucial in regulating inflammation in lung and heart injuries. However, its role in periodontitis remains unclear. We sought to elucidate the effects of circFOXO3 on periodontitis progression and related molecular mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Reverse\u2010transcription quantitative polymerase chain reaction and fluorescence in\u00a0situ hybridization were used to\u00a0quantify and localize circFOXO3 expression. The mechanism by which circFOXO3 promotes inflammation in periodontitis\u00a0was investigated using epithelial cells, human gingival epithelium and a rat model of ligature\u2010induced periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>circFOXO3 expression was abnormally high in the gingival epithelial tissues of patients with periodontitis. Elevated circFOXO3 levels down\u2010regulated microRNA (miR)\u2010141\u20103p, leading to increased FOXO3 expression. FOXO3 interacted with JunB to form a transcriptional\u2010repression complex that inhibited the integrin \u03b26 (ITG\u03b26)\u2010mediated activation of transforming growth factor \u03b2 (TGF\u2010\u03b2) in epithelial cells. Through the miR\u2010141\u20103p\/FOXO3\/JunB axis, circFOXO3 suppressed TGF\u2010\u03b2 signalling, thereby exacerbating periodontal inflammation. Finally, circFOXO3 inhibition hindered disease progression and restored TGF\u2010\u03b2 activity in\u00a0vivo via the FOXO3\/JunB\/ITG\u03b26 pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study identified a novel mechanism by which circFOXO3 contributes to periodontal inflammation through a complex transcriptional regulatory network involving miR\u2010141\u20103p, FOXO3, JunB and ITG\u03b26. These findings highlight potential therapeutic targets for the development of effective treatments for this debilitating disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.14124","type":"journal-article","created":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T20:20:42Z","timestamp":1736713242000},"page":"651-664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Targeting\n                    <scp>circFOXO3<\/scp>\n                    to Modulate Integrin \u03b26 Expression in Periodontitis: A Potential Therapeutic Approach"],"prefix":"10.1111","volume":"52","author":[{"given":"Mingyan","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Implantology Stomatological Hospital of Xiamen Medical College &amp; Xiamen Key Laboratory of Stomatological Disease Diagnosis and Treatment  Xiamen 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