{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:09:43Z","timestamp":1787015383986,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the feasibility of applying sequential, multiple assignment, randomized trial (SMART) design in periodontology and to assess the response of grade III furcation\u2010involved molars to various treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A member of the public served as a co\u2010investigator. Twenty participants with at least one grade III furcation\u2010involved molar tooth were randomized to either non\u2010surgical periodontal treatment (NSPT) or open\u2010flap debridement (OFD). They were reassessed 6\u2009months later, where \u2018successful response\u2019 to therapy was defined with a \u2018combined outcome\u2019 incorporating patient\u2010reported and clinical parameters. Based on SMART principles, non\u2010responders underwent further treatment and were followed up to 12\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All study feasibility criteria were met, except \u2018planned recruitment rate\u2019, which was slower than expected. At the 6\u2010month review, those who underwent OFD showed a greater reduction in probing pocket depth (PPD) compared to those who received NSPT (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009&lt;\u20090.01). \u2018Success\u2019 was reached by 6 out of 10 NSPT participants and by 7 out of 10 OFD participants. Non\u2010responders were further randomized and followed up to 12\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This SMART design is feasible in periodontology trials. This study demonstrates its advantages and limitations along with clinical and patient\u2010reported data of grade III furcations treated surgically or non\u2010surgically.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.14134","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T20:48:21Z","timestamp":1749070101000},"page":"932-939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical and Patient\u2010Reported Outcomes in Grade\n                    <scp>III<\/scp>\n                    Furcations: A Randomized Feasibility Trial With\u00a0\n                    <scp>SMART<\/scp>\n                    Design"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4166-3882","authenticated-orcid":false,"given":"Priya","family":"Bahal","sequence":"first","affiliation":[{"name":"Periodontology Unit, Centre for Host Microbiome Interactions, Dental Institute King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4102-1759","authenticated-orcid":false,"given":"Pasquale","family":"Santamaria","sequence":"additional","affiliation":[{"name":"Periodontology Unit, Centre for Host Microbiome Interactions, Dental Institute King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab","family":"Malaki","sequence":"additional","affiliation":[{"name":"Periodontology Unit, Centre for Host Microbiome Interactions, Dental Institute King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Redman","sequence":"additional","affiliation":[{"name":"Lewisham  London 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