{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T19:57:52Z","timestamp":1790452672222,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Sub\u2010gingival non\u2010surgical periodontal therapy (NSPT) constitutes step 2 of periodontal therapy, aiming to disrupt the subgingival microbial biofilm and resolve or reduce inflammation of the supracrestal periodontal tissues. A plethora of original studies and reviews have been published over several decades, highlighting its fundamental importance in periodontal therapy and in tooth survival. Evidence shows that step 2 therapy leads to probing pocket depth reduction, associated with increase in gingival recession, clinical attachment level gain and improvements in patient\u2010reported outcome measures, as well as to a reduction in local and, to some extent, systemic inflammatory markers. In cases of intrabony defects, NSPT has traditionally been considered a necessary step to improve periodontal tissue tone and reduce inflammation, thus paving the way for the surgical step, such as periodontal regeneration. This commentary presents compelling arguments for a paradigm shift showing that step 2 therapy also leads to changes in osseous morphology, particularly evident in, but probably not limited to, intrabony defects. This introduces a new dawn, where attempts should be made to understand the mechanisms behind this phenomenon and to maximise the potential of non\u2010surgical therapy to achieve disease resolution and defect\/pocket improvements while reducing patient morbidity even in complex periodontal defects.<\/jats:p>","DOI":"10.1111\/jcpe.14141","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T19:09:11Z","timestamp":1741892951000},"page":"836-842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Changes in Osseous Morphology Following Non\u2010Surgical Periodontal Therapy: A Possible Paradigm Shift for the Treatment of Intrabony Defects?"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7750-5010","authenticated-orcid":false,"given":"Luigi","family":"Nibali","sequence":"first","affiliation":[{"name":"Periodontology Unit, Centre for Host Microbiome Interactions, Faculty of Dentistry, Oral &amp; Craniofacial Sciences King's College London  London UK"},{"name":"Private Practice  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0937-2807","authenticated-orcid":false,"given":"Pierpaolo","family":"Cortellini","sequence":"additional","affiliation":[{"name":"Private Practice  Florence Italy"},{"name":"European Research Group on Periodontology (ERGOPERIO)  Bern Switzerland"},{"name":"Section of Periodontology, Department of Oral Health Sciences KU Leuven &amp; Dentistry, University Hospitals, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.5978\/islsm.16\u2010OR\u201011"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1974.45.9.6723"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.1356744"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13255"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.11s.1138"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010019\u201003188\u20101"},{"issue":"1","key":"e_1_2_4_8_1","first-page":"41","article-title":"Evaluation of a Mineralized Cancellous Bone Allograft for the Treatment of Periodontal Osseous Defects: 6\u2010Month Surgical Reentry","volume":"29","author":"Browning E. 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