{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:16:11Z","timestamp":1791213371183,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T00:00:00Z","timestamp":1741478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007885","name":"European Association for the Study of Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007885","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the effect of religious Bah\u00e1'\u00ed dry fasting (BF) or 16:8 time\u2010restricted eating (TRE) compared with a regular diet (CG) on periodontal parameters during a modified experimentally induced gingivitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>All participants were asked to refrain from oral hygiene (3 sextant) for 9\u2009days (T1\u2013T2) and were followed for a total of 19\u2009days (T3) while adhering to fasting or a regular diet and resuming oral hygiene. The primary outcome was bleeding on probing in the test sextant (BOP_s), Rustogi plaque index (RPI), gingival crevicular fluid (GCF), blood pressure (BP), body weight (BW), HbA1c and C\u2010reactive protein (CRP) were measured (T1\u2013T3) and ANCOVA and post hoc comparison were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010six healthy participants were recruited. Forty\u2010three were randomly assigned to TRE (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922) and CG (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200921), while 23 followed BF, avoiding food and drinks during the day. At T2, BF demonstrated significantly less increase in BOP_s, and GCF increased in CG only. Analysis revealed significant differences in change for BOP_s between BF and CG (\u22129.48% [\u221217.18; \u22121.79]) and BF and TRE (\u22129.19% [\u221215.07; \u22123.32]) as well as for GCF between BF and CG (\u22120.06\u2009\u03bcL [\u22127.22; \u22120.66]) and TRE and CG (\u22120.08\u2009\u03bcL [\u22120.17; \u22120.00]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study indicates beneficial effects of different fasting protocols on oral experimental gingivitis and metabolic parameters, but results are limited by randomisation issues and potential bias in the BF group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.14151","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T01:01:54Z","timestamp":1741741314000},"page":"681-694","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Intermittent Fasting Regimes Reduce Gingival Inflammation: A Three\u2010Arm Clinical Trial"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0645-704X","authenticated-orcid":false,"given":"C. L.","family":"Pappe","sequence":"first","affiliation":[{"name":"Department of Periodontology, Oral Medicine and Oral Surgery Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Maetschker","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Oral Medicine and Oral Surgery Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Dujardin","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dentistry, University School of Dental Medicine Martin Luther University Halle\u2010Wittenberg  Halle 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Epidemiology and Health Economics, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humbolt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Steckhan","sequence":"additional","affiliation":[{"name":"Digital Health\u2010Connected Healthcare, Hasso Plattner Institute University of Potsdam  Potsdam Germany"},{"name":"Evidence\u2010Based Digital Diabetology, Medical Faculty Carl Gustav Carus, Department of Medicine III, Prevention and Care of Type 2 Diabetes Technical University of Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Koppold","sequence":"additional","affiliation":[{"name":"German Center for Diabetes Research (DZD)  M\u00fcnchen\u2010Neuherberg Germany"},{"name":"Institute of Social Medicine, Epidemiology and Health Economics, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin Corporate Member 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