{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:02:20Z","timestamp":1787241740925,"version":"build-2736575974"},"reference-count":69,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This systematic review aimed to answer the question: In patients undergoing periodontal and peri\u2010implant surgery, gingival augmentation, implant site development or placement, are pre\u2010emptive analgesics effective in controlling post\u2010operative pain compared with patients not receiving pre\u2010emptive medications?<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>After comprehensive electronic and manual literature searches, randomised placebo\u2010controlled clinical trials on adults undergoing the aforementioned surgeries were included. A meta\u2010analysis was performed comparing pain (standardised mean difference) between pre\u2010emptive medication and placebo at post\u2010operative hours 1, 3, 6, 8, 24 and 72.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two reviewers screened 1995 titles, included 18 studies in the systematic review (open flap debridement, osseous, mucogingival, unspecified periodontal surgery, implant placement; 1008 patients) and 7 studies in the meta\u2010analysis. Non\u2010steroidal anti\u2010inflammatory drugs, acetaminophen and corticosteroids were prescribed 8\u2009h to immediately pre\u2010operatively and post\u2010operatively until 12\u2009h after the first dose. A clinically significant pain reduction peaked at 3\u2009h (\u22120.81 [95% CI: \u22121.03, \u22120.58]; 9 study arms,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009165 drug vs.\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200996 placebo patients) and was significant until 8\u2009h (\u22120.54 [95% CI: \u22120.79, \u22120.28]; 7 study arms,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009126 drug vs.\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200996 placebo patients), with moderate certainty of evidence (GRADE assessment).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pre\u2010emptive analgesia can reduce pain for up to 8\u2009h following periodontal and implant placement surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.14157","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T01:14:45Z","timestamp":1746666885000},"page":"1167-1195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pre\u2010Emptive Analgesia for Periodontal and Implant\u2010Related Surgery: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"52","author":[{"given":"Christos","family":"Gousias","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences, School of Dentistry Marquette University  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab","family":"Alsuwaiyan","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, School of Dentistry Marquette University  Milwaukee Wisconsin USA"},{"name":"Department of Preventive Dental Sciences, College of Dentistry Imam Abdulrahman Bin Faisal University  Dammam Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6927-434X","authenticated-orcid":false,"given":"Alissa","family":"Fial","sequence":"additional","affiliation":[{"name":"Raynor Memorial Libraries Marquette University  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengtong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of General Dental Sciences, School of Dentistry Marquette University  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6327-3610","authenticated-orcid":false,"given":"Dimitris N.","family":"Tatakis","sequence":"additional","affiliation":[{"name":"Department of Periodontics, School of Dental Medicine Case Western Reserve University  Cleveland Ohio USA"},{"name":"Department of Oral and Maxillofacial Surgery, Oral Medicine, and Periodontology, School of Dentistry University of Jordan  Amman Jordan"},{"name":"(previously) Division of Periodontology, College of Dentistry The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1272-1430","authenticated-orcid":false,"given":"Vrisiis","family":"Kofina","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, School of Dentistry Marquette University  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060032"},{"issue":"6","key":"e_1_2_11_3_1","article-title":"Paracetamol, NSAIDS and Opioid Analgesics for Chronic Low Back Pain: A Network Meta\u2010Analysis","volume":"2018","author":"Bagg M. K.","year":"2018","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160353"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(97)00049-8"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.02.004"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2007.0105"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2020.01.016"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-023-01258-1"},{"key":"e_1_2_11_10_1","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J.","year":"1988"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2015.06.012"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)65552-1"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1985.56.10.597"},{"issue":"6","key":"e_1_2_11_14_1","article-title":"Pre\u2010Emptive and Preventive NSAIDs for Postoperative Pain in Adults Undergoing all Types of Surgery","volume":"6","author":"Doleman B.","year":"2021","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050296"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.18433\/J3VW2F"},{"key":"e_1_2_11_17_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions (Version 6.5)","author":"Higgins J. P. T.","year":"2024"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2385"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2023.104605"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124X.153475"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0209264"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1385401"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080536"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14170"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.24639"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1074"},{"issue":"6","key":"e_1_2_11_27_1","first-page":"e723","article-title":"Preemptive Analgesia\u2010Related Gene and Protein Expression in Third Molar Surgeries Under Non\u2010Steroidal Anti\u2010Inflammatory Drug Protocols: A PROSPERO\u2010Registered Systematic Review of Clinical Studies","volume":"23","author":"Medeiros\u2010Albuquerque A. F.","year":"2018","journal-title":"Medicina Oral, Patolog\u00eda Oral y Cirug\u00eda Bucal"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12618"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199601000-00009"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1988.59.6.390"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200203000-00032"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-023-05362-y"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.842"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.12.1307"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000144428.98767.0E"},{"issue":"1","key":"e_1_2_11_36_1","first-page":"5","article-title":"Pathogenesis of Postoperative Oral Surgical Pain","volume":"50","author":"Ong C. K.","year":"2003","journal-title":"Anesthesia Progress"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2021.03.001"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.1997.tb00139.x"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.56171"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.060128"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-015-0060-8"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6450a3"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1037"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1563\/aaid-joi-D-17-00185"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2019.10.014"},{"issue":"2","key":"e_1_2_11_46_1","first-page":"298","article-title":"Preemptive Effects of Ibuprofen and Nimesulide on Postoperative Pain Control After Open Flap Periodontal Surgeries: A Randomized Placebo\u2010Controlled Split\u2010Mouth Clinical Trial","volume":"93","author":"Santos B. F. E.","year":"2022","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_47_1","volume-title":"Goodman & Gilman's: The Pharmacological Basis of Therapeutics","author":"Schimmer B. P.","year":"2017"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.886"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2009.11.005"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-024-03322-1"},{"issue":"6","key":"e_1_2_11_51_1","first-page":"354","article-title":"Postoperative Periodontal Pain Prevention Using Two Dexamethasone Medication Protocols: A Double\u2010Blind, Parallel\u2010Group, Placebo\u2010Controlled Randomized Clinical Trial","volume":"24","author":"Steffens J. P.","year":"2011","journal-title":"American Journal of Dentistry"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.100682"},{"issue":"1","key":"e_1_2_11_53_1","first-page":"85","article-title":"COX\u20102 Selective Nonsteroidal Anti\u2010Inflammatory Drugs and Pain Control After Periodontal Surgeries: A Pilot Study","volume":"60","author":"Steffens J. P.","year":"2012","journal-title":"Revista Ga\u00facha de Odontologia"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100059"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03530290046036"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200847110-00002"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12248"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1996.tb00545.x"},{"issue":"2","key":"e_1_2_11_59_1","first-page":"237","article-title":"Effect of Intravenous Dexamethasone on Postoperative Pain and Swelling Following Periodontal Flap Surgery: A Randomized Controlled Trial of Patient\u2010Centered Outcomes","volume":"93","author":"Vieth M. P.","year":"2022","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.11.914"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/cap.10169"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/0885-3924(92)90105-Q"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070325"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-022-01763-x"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00113-8"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.06314"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199377020-00026"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2022.08.038"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12794"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1677-32252013000400013"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.14157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T01:20:56Z","timestamp":1752542456000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.14157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,7]]},"references-count":69,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/jcpe.14157"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.14157","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,7]]},"assertion":[{"value":"2024-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}